Assessment of Structural Intolerance and Durability
General Structure Information 1nbq F11R crystal structure of human junctional adhesion molecule type 1 2.9Å AUTH A.E.PROTA,J.A.CAMPBELL,P.SCHELLING,J.C.FORREST,AUTH 2 M.J.WATSON,T.R.PETERS,M.AURRAND-LIONS,B.A.IMHOF,AUTH 3 T.S.DERMODY,T.STEHLETITL CRYSTAL STRUCTURE OF HUMAN JUNCTIONAL ADHESIONTITL 2 MOLECULE 1: IMPLICATIONS FOR REOVIRUS BINDINGREF PROC.NATL.ACAD.SCI.USA V. 100 5366 2003REFN ISSN 0027-8424PMID 12697893DOI 10.1073/PNAS.0937718100 Variant Set Distributions Mapped Variants
General Structure Information 2ch6 NAGK crystal structure of human n-acetylglucosamine kinase in complex with adp and glucose 2.72Å AUTH W.A.WEIHOFEN,M.BERGER,H.CHEN,W.SAENGER,S.HINDERLICHTITL STRUCTURES OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN TWOTITL 2 COMPLEXES WITH N-ACETYLGLUCOSAMINE AND WITH ADP/GLUCOSE:TITL 3 INSIGHTS INTO SUBSTRATE SPECIFICITY AND REGULATION.REF J.MOL.BIOL. V. 364 388 2006REFN ISSN 0022-2836PMID 17010375DOI 10.1016/J.JMB.2006.08.085 Variant Set Distributions Ripley’s K […]
General Structure Information 1mu9 TDP1 crystal structure of a human tyrosyl-dna phosphodiesterase (tdp1)- vanadate complex 2.05Å AUTH D.R.DAVIES,H.INTERTHAL,J.J.CHAMPOUX,W.G.J.HOLTITL INSIGHTS INTO SUBSTRATE BINDING AND CATALYTIC MECHANISM OFTITL 2 HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1) FROM VANADATE-TITL 3 AND TUNGSTATE-INHIBITED STRUCTURESREF J.MOL.BIOL. V. 324 917 2002REFN ISSN 0022-2836PMID 12470949DOI 10.1016/S0022-2836(02)01154-3 Variant Set Distributions Mapped Variants
General Structure Information 1kqo NMNAT1 crystal structure of nmn/namn adenylyltransferase complexed with deamido-nad 2.5Å AUTH T.ZHOU,O.KURNASOV,D.R.TOMCHICK,D.D.BINNS,N.V.GRISHIN,AUTH 2 V.E.MARQUEZ,A.L.OSTERMAN,H.ZHANGTITL STRUCTURE OF HHUMAN OF NICOTINAMIDE/NICOTINIC ACIDTITL 2 MONONUCLEOTIDE ADENYLYLTRANSFERASE. BASIS FOR THE DUALTITL 3 SUBSTRATE SPECIFICITY AND ACTIVATION OF THE ONCOLYTIC AGENTTITL 4 TIAZOFURIN.REF J.BIOL.CHEM. V. 277 13148 2002REFN ISSN 0021-9258PMID 11788603DOI 10.1074/JBC.M111469200 Variant Set Distributions Ripley’s […]
General Structure Information 3l0c CTDSP1 crystal structure of scp1 phosphatase d206a mutant with trapped inorganic phosphate 2.45Å AUTH M.ZHANG,J.LIU,Y.KIM,J.E.DIXON,S.L.PFAFF,G.N.GILL,J.P.NOEL,AUTH 2 Y.ZHANGTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PHOSPHORYLTITL 2 TRANSFER REACTION MEDIATED BY THE HUMAN SMALL C-TERMINALTITL 3 DOMAIN PHOSPHATASE, SCP1.REF PROTEIN SCI. V. 19 974 2010REFN ISSN 0961-8368PMID 20222012DOI 10.1002/PRO.375 Variant Set Distributions Mapped […]
General Structure Information 4ifp NLRP1 x-ray crystal structure of human nlrp1 card domain 1.99Å AUTH T.JIN,J.CURRY,P.SMITH,J.JIANG,T.S.XIAOTITL STRUCTURE OF THE NLRP1 CASPASE RECRUITMENT DOMAIN SUGGESTSTITL 2 POTENTIAL MECHANISMS FOR ITS ASSOCIATION WITH PROCASPASE-1.REF PROTEINS V. 81 1266 2013REFN ISSN 0887-3585PMID 23508996DOI 10.1002/PROT.24287 Variant Set Distributions Mapped Variants
General Structure Information 2fue PMM1 human alpha-phosphomannomutase 1 with d-mannose 1-phosphate and mg2+ cofactor bound 1.75Å AUTH N.R.SILVAGGI,C.ZHANG,Z.LU,J.DAI,D.DUNAWAY-MARIANO,K.N.ALLENTITL THE X-RAY CRYSTAL STRUCTURES OF HUMANTITL 2 ALPHA-PHOSPHOMANNOMUTASE 1 REVEAL THE STRUCTURAL BASIS OFTITL 3 CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1A.REF J.BIOL.CHEM. V. 281 14918 2006REFN ISSN 0021-9258PMID 16540464DOI 10.1074/JBC.M601505200 Variant Set Distributions Mapped Variants
General Structure Information 4hwn FCRLA crystal structure of the second ig-c2 domain of human fc-receptor like a (fcrla), isoform 9 [nysgrc-005836] 2.01Å AUTH P.R.KUMAR,S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE SECOND IG-C2 DOMAIN OF THE HUMANTITL 2 FC-RECEPTOR LIKE A, ISOFORM 9 [NYSGRC-005836]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3qj4 RNLS crystal structure of human renalase (isoform 1) 2.5Å AUTH M.MILANI,F.CIRIELLO,S.BARONI,V.PANDINI,G.CANEVARI,AUTH 2 M.BOLOGNESI,A.ALIVERTITITL FAD-BINDING SITE AND NADP REACTIVITY IN HUMAN RENALASE: ATITL 2 NEW ENZYME INVOLVED IN BLOOD PRESSURE REGULATIONREF J.MOL.BIOL. V. 411 463 2011REFN ISSN 0022-2836PMID 21699903DOI 10.1016/J.JMB.2011.06.010 Variant Set Distributions Mapped Variants
General Structure Information 4hcr MADCAM1 crystal structure of human madcam-1 d1d2 complexed with fab pf-547659 2.3Å AUTH T.SPRINGER,Y.YU,J.ZHU,J.-H.WANG,P.-S.HUANGTITL A DIFFERENT FOLD WITH AN INTEGRIN-BINDING LOOP SPECIALIZEDTITL 2 FOR FLEXIBILITY IN MUCOSAL ADDRESSIN CELL ADHESIONTITL 3 MOLECULE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants