Assessment of Structural Intolerance and Durability
General Structure Information 1k8f CAP1 crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein 2.8Å AUTH T.DODATKO,A.A.FEDOROV,M.GRYNBERG,Y.PATSKOVSKY,D.A.ROZWARSKI,AUTH 2 L.JAROSZEWSKI,E.ARONOFF-SPENCER,E.KONDRASKINA,T.IRVING,AUTH 3 A.GODZIK,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE ACTIN BINDING DOMAIN OF THETITL 2 CYCLASE-ASSOCIATED PROTEIN.REF BIOCHEMISTRY V. 43 10628 2004REFN ISSN 0006-2960PMID 15311924DOI 10.1021/BI049071R Variant Set Distributions Mapped Variants
General Structure Information 1k8f CAP1 crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein 2.8Å AUTH T.DODATKO,A.A.FEDOROV,M.GRYNBERG,Y.PATSKOVSKY,D.A.ROZWARSKI,AUTH 2 L.JAROSZEWSKI,E.ARONOFF-SPENCER,E.KONDRASKINA,T.IRVING,AUTH 3 A.GODZIK,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE ACTIN BINDING DOMAIN OF THETITL 2 CYCLASE-ASSOCIATED PROTEIN.REF BIOCHEMISTRY V. 43 10628 2004REFN ISSN 0006-2960PMID 15311924DOI 10.1021/BI049071R Variant Set Distributions Mapped Variants
General Structure Information 1k8f CAP1 crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein 2.8Å AUTH T.DODATKO,A.A.FEDOROV,M.GRYNBERG,Y.PATSKOVSKY,D.A.ROZWARSKI,AUTH 2 L.JAROSZEWSKI,E.ARONOFF-SPENCER,E.KONDRASKINA,T.IRVING,AUTH 3 A.GODZIK,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE ACTIN BINDING DOMAIN OF THETITL 2 CYCLASE-ASSOCIATED PROTEIN.REF BIOCHEMISTRY V. 43 10628 2004REFN ISSN 0006-2960PMID 15311924DOI 10.1021/BI049071R Variant Set Distributions Mapped Variants
General Structure Information 1q7l ACY1 zn-binding domain of the t347g mutant of human aminoacylase- i 1.4Å AUTH H.A.LINDNER,V.V.LUNIN,A.ALARY,R.HECKER,M.CYGLER,AUTH 2 R.MENARDTITL ESSENTIAL ROLES OF ZINC LIGATION AND ENZYMETITL 2 DIMERIZATION FOR CATALYSIS IN THETITL 3 AMINOACYLASE-1/M20 FAMILY.REF J.BIOL.CHEM. V. 278 44496 2003REFN ISSN 0021-9258PMID 12933810DOI 10.1074/JBC.M304233200 Variant Set Distributions Mapped Variants
General Structure Information 1q7l ACY1 zn-binding domain of the t347g mutant of human aminoacylase- i 1.4Å AUTH H.A.LINDNER,V.V.LUNIN,A.ALARY,R.HECKER,M.CYGLER,AUTH 2 R.MENARDTITL ESSENTIAL ROLES OF ZINC LIGATION AND ENZYMETITL 2 DIMERIZATION FOR CATALYSIS IN THETITL 3 AMINOACYLASE-1/M20 FAMILY.REF J.BIOL.CHEM. V. 278 44496 2003REFN ISSN 0021-9258PMID 12933810DOI 10.1074/JBC.M304233200 Variant Set Distributions Mapped Variants
General Structure Information 1q7l ACY1 zn-binding domain of the t347g mutant of human aminoacylase- i 1.4Å AUTH H.A.LINDNER,V.V.LUNIN,A.ALARY,R.HECKER,M.CYGLER,AUTH 2 R.MENARDTITL ESSENTIAL ROLES OF ZINC LIGATION AND ENZYMETITL 2 DIMERIZATION FOR CATALYSIS IN THETITL 3 AMINOACYLASE-1/M20 FAMILY.REF J.BIOL.CHEM. V. 278 44496 2003REFN ISSN 0021-9258PMID 12933810DOI 10.1074/JBC.M304233200 Variant Set Distributions Mapped Variants
General Structure Information 2qym PDE4C crystal structure of unliganded pde4c2 1.9Å AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dt7 SF3A3 solution structure of the second surp domain of human splicing factor sf3a120 in complex with a fragment of human splicing factor sf3a60 -1.0Å AUTH K.KUWASAKO,F.HE,M.INOUE,A.TANAKA,S.SUGANO,AUTH 2 P.GUENTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SURP DOMAINS AND THETITL 2 SUBUNIT-ASSEMBLY MECHANISM WITHIN THE SPLICINGTITL 3 FACTOR SF3A COMPLEX IN 17S U2 SNRNPREF STRUCTURE […]
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants