Assessment of Structural Intolerance and Durability
General Structure Information 3llm DHX9 crystal structure analysis of a rna helicase 2.8Å AUTH P.SCHUTZ,E.WAHLBERG,T.KARLBERG,M.HAMMARSTROM,R.COLLINS,AUTH 2 A.FLORES,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN RNA HELICASE A (DHX9): STRUCTURALTITL 2 BASIS FOR UNSELECTIVE NUCLEOTIDE BASE BINDING IN A DEAD-BOXTITL 3 VARIANT PROTEIN.REF J.MOL.BIOL. V. 400 768 2010REFN ISSN 0022-2836PMID 20510246DOI 10.1016/J.JMB.2010.05.046 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2fh7 PTPRS crystal structure of the phosphatase domains of human ptp sigma 2.0Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2cpe EWSR1 solution structure of the rna recognition motif of ewing sarcoma(ews) protein -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OFTITL 2 EWING SARCOMA(EWS) PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l33 ILF3 solution nmr structure of drbm 2 domain of interleukin enhancer- binding factor 3 from homo sapiens, northeast structural genomics consortium target hr4527e -1.0Å AUTH G.LIU,H.JANJUA,R.XIAO,T.B.ACTON,J.EVERETT,G.T.MONTELIONETITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4527EREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yuq ITK solution structure of the sh3 domain of human tyrosine- protein kinase itk/tsk -1.0Å AUTH H.ABE,K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,AUTH 2 T.HARADA,S.WATANABE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE ITK/TSKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t5c CENPE crystal structure of the motor domain of human kinetochore protein cenp-e 2.5Å AUTH I.GARCIA-SAEZ,T.YEN,R.H.WADE,F.KOZIELSKITITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF THE HUMANTITL 2 KINETOCHORE PROTEIN CENP-E.REF J.MOL.BIOL. V. 340 1107 2004REFN ISSN 0022-2836PMID 15236970DOI 10.1016/J.JMB.2004.05.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i2b PTS the crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase 2.3Å AUTH E.UGOCHUKWU,R.COCKING,E.PILKA,W.W.YUE,J.E.BRAY,A.CHAIKUAD,AUTH 2 T.KROJER,J.MUNIZ,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN 6 PYRUVOYLTITL 2 TETRAHYDROBIOPTERIN SYNTHASEREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2enj PRKCQ solution sturcture of the c2 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STURCTURE OF THE C2 DOMAIN FROM HUMANTITL 2 PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants