Assessment of Structural Intolerance and Durability
General Structure Information 1yjr ATP7A solution structure of the apo form of the sixth soluble domain a69p mutant of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,A.ROSATO,AUTH 2 S.WANGTITL AN ATOMIC-LEVEL INVESTIGATION OF THETITL 2 DISEASE-CAUSING A629P MUTANT OF THE MENKESTITL 3 PROTEIN, ATP7AREF J.MOL.BIOL. V. 352 409 2005REFN ISSN 0022-2836PMID 16083905DOI 10.1016/J.JMB.2005.07.034 Variant Set Distributions Mapped Variants
General Structure Information 1yjr ATP7A solution structure of the apo form of the sixth soluble domain a69p mutant of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,A.ROSATO,AUTH 2 S.WANGTITL AN ATOMIC-LEVEL INVESTIGATION OF THETITL 2 DISEASE-CAUSING A629P MUTANT OF THE MENKESTITL 3 PROTEIN, ATP7AREF J.MOL.BIOL. V. 352 409 2005REFN ISSN 0022-2836PMID 16083905DOI 10.1016/J.JMB.2005.07.034 Variant Set Distributions Mapped Variants
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3rcq ASPH crystal structure of human aspartate beta-hydroxylase isoform a 2.05Å AUTH T.KROJER,G.KOCHAN,E.PILKA,V.HOZJAN,C.K.ALLERSTON,J.BRAY,AUTH 2 J.R.MUNIZ,A.CHAIKUAD,O.GILEADI,K.KAVANAGH,F.VON DELFT,AUTH 3 C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ASPARTATE BETA-HYDROXYLASETITL 2 ISOFORM AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 2gtp RGS1 crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1 2.55Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K […]