Assessment of Structural Intolerance and Durability
General Structure Information 2gw6 TSEN15 nmr structure of the human trna endonuclease sen15 subunit -1.0Å AUTH J.SONG,J.L.MARKLEYTITL THREE-DIMENSIONAL STRUCTURE DETERMINED FOR ATITL 2 SUBUNIT OF HUMAN TRNA SPLICING ENDONUCLEASETITL 3 (SEN15) REVEALS A NOVEL DIMERIC FOLD.REF J.MOL.BIOL. V. 366 155 2007REFN ISSN 0022-2836PMID 17166513DOI 10.1016/J.JMB.2006.11.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2qep PTPRN2 crystal structure of the d1 domain of ptprn2 (ia2beta) 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2a98 ITPKC crystal structure of the catalytic domain of human inositol 1,4,5- trisphosphate 3-kinase c 2.6Å AUTH B.M.HALLBERG,D.OGG,C.ARROWSMITH,A.EDWARDS,M.EHN,S.GRASLUND,AUTH 2 M.HAMMARSTROM,T.KOTENYOVA,P.NILSSON-EHLE,P.NORDLUND,AUTH 3 C.PERSSON,J.SAGEMARK,H.SCHULER,P.STENMARK,A.-G.THORSELL,AUTH 4 M.SUNDSTROM,J.WEIGELTTITL THE CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i4r NUP133 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cra HOXB13 solution structure of the homeobox domain of human homeo box b13 -1.0Å AUTH K.SEIMIYA,F.HAYASHI,T.NAGASHIMA,M.YOSHIDA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HOMEOBOX DOMAIN OF HUMANTITL 2 HOMEO BOX B13REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3c0y HDAC7 crystal structure of catalytic domain of human histone deacetylase hdac7 2.1Å AUTH A.SCHUETZ,J.MIN,A.ALLALI-HASSANI,M.SCHAPIRA,AUTH 2 M.SHUEN,P.LOPPNAU,R.MAZITSCHEK,N.P.KWIATKOWSKI,AUTH 3 T.A.LEWIS,R.L.MAGLATHIN,T.H.MCLEAN,A.BOCHKAREV,AUTH 4 A.N.PLOTNIKOV,M.VEDADI,C.H.ARROWSMITHTITL HUMAN HDAC7 HARBORS A CLASS IIA HISTONETITL 2 DEACETYLASE-SPECIFIC ZINC BINDING MOTIF AND CRYPTICTITL 3 DEACETYLASE ACTIVITY.REF J.BIOL.CHEM. V. 283 11355 2008REFN ISSN 0021-9258PMID 18285338DOI 10.1074/JBC.M707362200 Variant Set Distributions Mapped Variants
General Structure Information 3mb3 PHIP crystal structure of the second bromodomain of pleckstrin homology domain interacting protein (phip) 2.25Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 2huz GNPNAT1 crystal structure of gnpnat1 2.67Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF GLUCOSAMINE-PHOSPHATETITL 2 N-ACETYLTRANSFERASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uey NRCAM solution structure of the first fibronectin type iii domain of human kiaa0343 protein -1.0Å AUTH C.ZHAO,T.KIGAWA,Y.MUTO,S.KOSHIBA,N.TOCHIO,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN KIAA0343 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1um7 DLG3 solution structure of the third pdz domain of synapse- associated protein 102 -1.0Å AUTH X.-R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD PDZ DOMAIN OFTITL 2 SYNAPSE-ASSOCIATED PROTEIN 102REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants