Assessment of Structural Intolerance and Durability
General Structure Information 3nwn KIF9 crystal structure of the human kif9 motor domain in complex with adp 2.0Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF9 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kt0 NANOG solution structure of human stem cell transcription factor nanog homeodomain fragment -1.0Å AUTH S.C.SAHU,J.L.MARKLEYTITL SOLUTION STRUCTURE OF HUMAN STEM CELL TRANSCRIPTION FACTORTITL 2 NANOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3llu RRAGC crystal structure of the nucleotide-binding domain of ras- related gtp-binding protein c 1.4Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,N.ZHONG,AUTH 2 X.GUAN,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE NUCLEOTIDE-BINDING DOMAINTITL 2 OF RAS-RELATED GTP-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ds4 TRIM45 solution structure of the filamin domain from human tripartite motif protein 45 -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FILAMIN DOMAIN FROMTITL 2 HUMAN TRIPARTITE MOTIF PROTEIN 45REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l46 ECT2 crystal structure of the second brct domain of epithelial cell transforming 2 (ect2) 1.48Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,H.WANG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SECOND BRCT DOMAIN OF EPITHELIALTITL 2 CELL TRANSFORMING 2 (ECT2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3mqm ASH1L crystal structure of the bromodomain of human ash1l 2.54Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4lg6 ANKRA2 crystal structure of ankra2-ccdc8 complex 1.8Å AUTH J.NIE,C.XU,J.JIN,J.A.AKA,W.TEMPEL,V.NGUYEN,L.YOU,R.WEIST,AUTH 2 J.MIN,T.PAWSON,X.J.YANGTITL ANKYRIN REPEATS OF ANKRA2 RECOGNIZE A PXLPXL MOTIF ON THE 3MTITL 2 SYNDROME PROTEIN CCDC8.REF STRUCTURE V. 23 700 2015REFN ISSN 0969-2126PMID 25752541DOI 10.1016/J.STR.2015.02.001 Variant Set Distributions Mapped Variants
General Structure Information 2ab1 AAMDC x-ray structure of gene product from homo sapiens hs.95870 2.59Å AUTH CENTER FOR EUKARYOTIC STRUCTURAL GENOMICS (CESG)TITL X-RAY STRUCTURE OF GENE PRODUCT FROM HOMO SAPIENS HS.95870REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cre CASS4 solution structure of rsgi ruh-036, an sh3 domain from human cdna -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-036, AN SH3 DOMAINTITL 2 FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ocb RAB9B crystal structure of human rab9b in complex with a gtp analogue 2.2Å AUTH B.HONG,L.SHEN,J.R.WALKER,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB9B IN COMPLEX WITH ATITL 2 GTP ANALOGUEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants