Assessment of Structural Intolerance and Durability
General Structure Information 1few DIABLO crystal structure of smac/diablo 2.2Å AUTH J.CHAI,C.DU,J.W.WU,S.KYIN,X.WANG,Y.SHITITL STRUCTURAL AND BIOCHEMICAL BASIS OF APOPTOTIC ACTIVATION BYTITL 2 SMAC/DIABLO.REF NATURE V. 406 855 2000REFN ISSN 0028-0836PMID 10972280DOI 10.1038/35022514 Variant Set Distributions Mapped Variants
General Structure Information 1xb0 BIRC8 structure of the bir domain of iap-like protein 2 2.2Å AUTH H.SHIN,M.RENATUS,B.P.ECKELMAN,V.A.NUNES,AUTH 2 C.A.M.SAMPAIO,G.S.SALVESENTITL THE BIR DOMAIN OF IAP-LIKE PROTEIN 2 ISTITL 2 CONFORMATIONALLY UNSTABLE: IMPLICATIONS FORTITL 3 CASPASE INHIBITIONREF BIOCHEM.J. V. 385 1 2005REFN ISSN 0264-6021PMID 15485395DOI 10.1042/BJ20041107 Variant Set Distributions Mapped Variants
General Structure Information 3t6p BIRC2 iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization 1.9Å AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]