Assessment of Structural Intolerance and Durability
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 4g1c SIRT5 human sirt5 bound to succ-idh2 and carba-nad 1.94Å AUTH B.G.SZCZEPANKIEWICZ,H.DAI,K.J.KOPPETSCH,D.QIAN,F.JIANG,AUTH 2 C.MAO,R.B.PERNITITL SYNTHESIS OF CARBA-NAD AND THE STRUCTURES OF ITS TERNARYTITL 2 COMPLEXES WITH SIRT3 AND SIRT5.REF J.ORG.CHEM. V. 77 7319 2012REFN ISSN 0022-3263PMID 22849721DOI 10.1021/JO301067E Variant Set Distributions Mapped Variants
General Structure Information 3zgo SIRT2 re-refined structure of the human sirt2 apoform 1.63Å AUTH S.MONIOT,M.SCHUTKOWSKI,C.STEEGBORNTITL CRYSTAL STRUCTURE ANALYSIS OF HUMAN SIRT2 AND ITSTITL 2 ADP-RIBOSE COMPLEXREF J.STRUCT.BIOL. V. 182 136 2013REFN ISSN 1047-8477PMID 23454361DOI 10.1016/J.JSB.2013.02.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants