Assessment of Structural Intolerance and Durability
General Structure Information 4o9b STIM1 the structure of cc1-ih in human stim1. 2.6Å AUTH B.CUI,X.YANG,S.LI,Z.LIN,Z.WANG,C.DONG,Y.SHENTITL THE INHIBITORY HELIX CONTROLS THE INTRAMOLECULARTITL 2 CONFORMATIONAL SWITCHING OF THE C-TERMINUS OF STIM1.REF PLOS ONE V. 8 74735 2013REFN ESSN 1932-6203PMID 24069340DOI 10.1371/JOURNAL.PONE.0074735 Variant Set Distributions Mapped Variants
General Structure Information 1x6d IL16 solution structures of the pdz domain of human interleukin- 16 -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE PDZ DOMAIN OF HUMANTITL 2 INTERLEUKIN-16REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a4p CYTH1 crystal structure of the sec7 domain from human cytohesin1 2.0Å AUTH J.C.ZEEH,A.W.THOMPSON,J.CHERFILS,V.BIOUTITL CRYSTAL STRUCTURE OF THE SEC7 DOMAIN FROM HUMAN CYTOHESIN1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hi9 ILK 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with pinch1 lim1 domain collected at wavelength 0.91974 1.2Å AUTH A.L.STIEGLER,J.JAKONCIC,V.STOJANOFF,B.P.CHISWELL,AUTH 2 D.A.CALDERWOOD,T.J.BOGGONTITL 1.2 STRUCTURE OF INTEGRIN-LINKED KINASE ANKYRIN REPEATTITL 2 DOMAIN IN COMPLEX WITH PINCH1 LIM1 DOMAIN COLLECTED ATTITL 3 WAVELENGTH 0.91974REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 3mq4 GRM7 metabotropic glutamate receptor mglur7 complexed with ly341495 antagonist 2.8Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,H.HE,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,A.BOCHKAREVTITL MGLUR7 COMPLEXED WITH LY341495REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fyv TLR1 crystal structure of the tir domain of human tlr1 2.9Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,AUTH 2 L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Mapped Variants
General Structure Information 1fyv TLR1 crystal structure of the tir domain of human tlr1 2.9Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,AUTH 2 L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Mapped Variants
General Structure Information 1fyv TLR1 crystal structure of the tir domain of human tlr1 2.9Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,AUTH 2 L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Mapped Variants
General Structure Information 2c5d GAS6 structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fg5 RAB31 crystal structure of human rab31 in complex with a gtp analogue 2.8Å AUTH J.WANG,W.TEMPEL,S.ISMAIL,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB31 IN COMPLEX WITH ATITL 2 GTP ANALOGUEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants