Assessment of Structural Intolerance and Durability
General Structure Information 1yxm PECR crystal structure of peroxisomal trans 2-enoyl coa reductase 1.9Å AUTH A.JANSSON,S.NG,C.ARROWSMITH,S.SHARMA,A.M.EDWARDS,AUTH 2 F.VON DELFT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF PERIXOMAL TRANS 2-ENOYL COATITL 2 REDUCTASE (PECRA)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qq5 DHRS1 crystal structure of human sdr family member 1 1.8Å AUTH E.S.PILKA,V.HOZJAN,E.UGOCHUKWU,F.VON DELFT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN SDR FAMILY MEMBER 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pd6 HSD17B8 structure of human hydroxysteroid dehydrogenase type 8, hsd17b8 2.0Å AUTH A.P.TURNBULL,E.SALAH,O.GILEADI,P.SAVITSKY,K.GUO,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,AUTH 3 C.H.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN HYDROXYSTEROID DEHYDROGENASE TYPE 8,TITL 2 HSD17B8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gll UXS1 crystal structure of human udp-xylose synthase. 2.5Å AUTH S.J.POLIZZI,R.M.WALSH,W.B.PEEPLES,J.M.LIM,L.WELLS,Z.A.WOODTITL HUMAN UDP-ALPHA-D-XYLOSE SYNTHASE AND ESCHERICHIA COLI ARNATITL 2 CONSERVE A CONFORMATIONAL SHUNT THAT CONTROLS WHETHER XYLOSETITL 3 OR 4-KETO-XYLOSE IS PRODUCED.REF BIOCHEMISTRY V. 51 8844 2012REFN ISSN 0006-2960PMID 23072385DOI 10.1021/BI301135B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1i3n GALE molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m- substituted udp-galactose 4-epimerase 1.5Å AUTH J.B.THODEN,T.M.WOHLERS,J.L.FRIDOVICH-KEIL,AUTH 2 H.M.HOLDENTITL MOLECULAR BASIS FOR SEVERE EPIMERASE DEFICIENCYTITL 2 GALACTOSEMIA. X-RAY STRUCTURE OF THE HUMANTITL 3 V94M-SUBSTITUTED UDP-GALACTOSE 4-EPIMERASE.REF J.BIOL.CHEM. V. 276 20617 2001REFN ISSN 0021-9258PMID 11279193DOI 10.1074/JBC.M101304200 Variant Set Distributions Pathogenic […]
General Structure Information 1zbq HSD17B4 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 4 in complex with nad 2.71Å AUTH P.LUKACIK,N.SHAFQAT,K.KAVANAGH,J.BRAY,F.VON DELFT,A.EDWARDS,AUTH 2 C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE 4 IN COMPLEX WITH NADREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants