Assessment of Structural Intolerance and Durability
General Structure Information 4d8k LCK crystal structure of a sh3-sh2 domains of a lymphocyte-specific protein tyrosine kinase (lck) from homo sapiens at 2.36 a resolution 2.36Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGYTITL CRYSTAL STRUCTURE OF A SH3-SH2 DOMAINS OF ATITL 2 LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (LCK) FROM HOMOTITL 3 […]
General Structure Information 1d4t SH2D1A crystal structure of the xlp protein sap in complex with a slam peptide 1.1Å AUTH F.POY,M.B.YAFFE,J.SAYOS,K.SAXENA,M.MORRA,J.SUMEGI,AUTH 2 L.C.CANTLEY,C.TERHORST,M.J.ECKTITL CRYSTAL STRUCTURES OF THE XLP PROTEIN SAP REVEAL ATITL 2 CLASS OF SH2 DOMAINS WITH EXTENDED,TITL 3 PHOSPHOTYROSINE-INDEPENDENT SEQUENCE RECOGNITION.REF MOL.CELL V. 4 555 1999REFN ISSN 1097-2765PMID 10549287DOI 10.1016/S1097-2765(00)80206-3 Variant Set Distributions […]
General Structure Information 2jxb NCK2 structure of cd3epsilon-nck2 first sh3 domain complex -1.0Å AUTH K.TAKEUCHI,H.YANG,E.NG,S.Y.PARK,Z.Y.SUN,AUTH 2 E.L.REINHERZ,G.WAGNERTITL STRUCTURAL AND FUNCTIONAL EVIDENCE THAT NCKTITL 2 INTERACTION WITH CD3EPSILON REGULATES T-CELLTITL 3 RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 380 704 2008REFN ISSN 0022-2836PMID 18555270DOI 10.1016/J.JMB.2008.05.037 Variant Set Distributions Mapped Variants
General Structure Information 2k4p INPPL1 solution structure of ship2-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL NMR STUDIES OF A HETEROTYPIC SAM-SAM DOMAINTITL 2 ASSOCIATION: THE INTERACTION BETWEEN THE LIPIDTITL 3 PHOSPHATASE SHIP2 AND THE EPHA2 RECEPTOR.REF BIOCHEMISTRY V. 47 12721 2008REFN ISSN 0006-2960PMID 18991394DOI 10.1021/BI801713F Variant Set Distributions Mapped Variants
General Structure Information 1z3k NCK2 structural insight into the binding diversity between the tyr-phosphorylated human ephrinbs and nck2 sh2 domain -1.0Å AUTH X.RAN,J.SONGTITL STRUCTURAL INSIGHT INTO THE BINDING DIVERSITYTITL 2 BETWEEN THE TYR-PHOSPHORYLATED HUMAN EPHRINBS ANDTITL 3 NCK2 SH2 DOMAIN.REF J.BIOL.CHEM. V. 280 19205 2005REFN ISSN 0021-9258PMID 15764601DOI 10.1074/JBC.M500330200 Variant Set Distributions Mapped Variants