Assessment of Structural Intolerance and Durability
General Structure Information 3db5 PRDM4 crystal structure of methyltransferase domain of human pr domain- containing protein 4 2.15Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 PR DOMAIN-CONTAINING PROTEIN 4.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qq8 TBC1D14 crystal structure of the putative rabgap domain of human tbc1 domain family member 14 2.0Å AUTH Y.TONG,W.TEMPEL,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OFTITL 2 HUMAN TBC1 DOMAIN FAMILY MEMBER 14.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1zd8 AK3 structure of human adenylate kinase 3 like 1 1.48Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADENYLATE KINASE 3 LIKE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3nwn KIF9 crystal structure of the human kif9 motor domain in complex with adp 2.0Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF9 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3llu RRAGC crystal structure of the nucleotide-binding domain of ras- related gtp-binding protein c 1.4Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,N.ZHONG,AUTH 2 X.GUAN,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE NUCLEOTIDE-BINDING DOMAINTITL 2 OF RAS-RELATED GTP-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l46 ECT2 crystal structure of the second brct domain of epithelial cell transforming 2 (ect2) 1.48Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,H.WANG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SECOND BRCT DOMAIN OF EPITHELIALTITL 2 CELL TRANSFORMING 2 (ECT2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3mqm ASH1L crystal structure of the bromodomain of human ash1l 2.54Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4lg6 ANKRA2 crystal structure of ankra2-ccdc8 complex 1.8Å AUTH J.NIE,C.XU,J.JIN,J.A.AKA,W.TEMPEL,V.NGUYEN,L.YOU,R.WEIST,AUTH 2 J.MIN,T.PAWSON,X.J.YANGTITL ANKYRIN REPEATS OF ANKRA2 RECOGNIZE A PXLPXL MOTIF ON THE 3MTITL 2 SYNDROME PROTEIN CCDC8.REF STRUCTURE V. 23 700 2015REFN ISSN 0969-2126PMID 25752541DOI 10.1016/J.STR.2015.02.001 Variant Set Distributions Mapped Variants
General Structure Information 2ocb RAB9B crystal structure of human rab9b in complex with a gtp analogue 2.2Å AUTH B.HONG,L.SHEN,J.R.WALKER,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB9B IN COMPLEX WITH ATITL 2 GTP ANALOGUEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3i3n KLHL11 crystal structure of the btb-back domains of human klhl11 2.6Å AUTH J.W.MURRAY,C.D.O.COOPER,T.KROJER,P.MAHAJAN,E.SALAH,AUTH 2 T.KEATES,P.SAVITSKY,A.C.W.PIKE,A.ROOS,J.MUNIZ,AUTH 3 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 4 A.EDWARDS,S.KNAPP,A.BULLOCK,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMANTITL 2 KLHL11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants