Assessment of Structural Intolerance and Durability
General Structure Information 4dy0 SERPINE2 crystal structure of native protease nexin-1 with heparin 2.35Å AUTH W.LI,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF PROTEASE NEXIN-1 IN COMPLEX WITHTITL 2 HEPARIN AND THROMBIN SUGGEST A 2-STEP RECOGNITION MECHANISM.REF BLOOD V. 120 459 2012REFN ISSN 0006-4971PMID 22618708DOI 10.1182/BLOOD-2012-03-415869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1as4 SERPINA3 cleaved antichymotrypsin a349r 2.1Å AUTH C.M.LUKACS,H.RUBIN,D.W.CHRISTIANSONTITL ENGINEERING AN ANION-BINDING CAVITY INTITL 2 ANTICHYMOTRYPSIN MODULATES THE SPRING-LOADEDTITL 3 SERPIN-PROTEASE INTERACTION.REF BIOCHEMISTRY V. 37 3297 1998REFN ISSN 0006-2960PMID 9521649DOI 10.1021/BI972359E Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1jmo SERPIND1 crystal structure of the heparin cofactor ii-s195a thrombin complex 2.2Å AUTH T.P.BAGLIN,R.W.CARRELL,F.C.CHURCH,C.T.ESMON,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF NATIVE AND THROMBIN-COMPLEXED HEPARINTITL 2 COFACTOR II REVEAL A MULTISTEP ALLOSTERIC MECHANISM.REF PROC.NATL.ACAD.SCI.USA V. 99 11079 2002REFN ISSN 0027-8424PMID 12169660DOI 10.1073/PNAS.162232399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1lq8 SERPINA5 crystal structure of cleaved protein c inhibitor 2.4Å AUTH J.A.HUNTINGTON,M.KJELLBERG,J.STENFLOTITL CRYSTAL STRUCTURE OF PROTEIN C INHIBITOR PROVIDES INSIGHTSTITL 2 INTO HORMONE BINDING AND HEPARIN ACTIVATIONREF STRUCTURE V. 11 205 2003REFN ISSN 0969-2126PMID 12575940DOI 10.1016/S0969-2126(02)00944-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lq8 SERPINA5 crystal structure of cleaved protein c inhibitor 2.4Å AUTH J.A.HUNTINGTON,M.KJELLBERG,J.STENFLOTITL CRYSTAL STRUCTURE OF PROTEIN C INHIBITOR PROVIDES INSIGHTSTITL 2 INTO HORMONE BINDING AND HEPARIN ACTIVATIONREF STRUCTURE V. 11 205 2003REFN ISSN 0969-2126PMID 12575940DOI 10.1016/S0969-2126(02)00944-9 Variant Set Distributions Mapped Variants
General Structure Information 3ut3 SERPINE1 a novel pai-i inhibitor and its structural mechanism 2.42Å AUTH Z.H.LIN,Z.B.HONG,X.L.SHI,L.H.HU,P.A.ANDREASEN,M.D.HUANGTITL A NOVEL PAI-I INHIBITOR AND ITS STRUCTURAL MECHANISMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1psi SERPINA1 intact recombined alpha1-antitrypsin mutant phe 51 to leu 2.92Å AUTH P.R.ELLIOTT,D.A.LOMAS,R.W.CARRELL,J.P.ABRAHAMSTITL INHIBITORY CONFORMATION OF THE REACTIVE LOOP OFTITL 2 ALPHA 1-ANTITRYPSIN.REF NAT.STRUCT.BIOL. V. 3 676 1996REFN ISSN 1072-8368PMID 8756325DOI 10.1038/NSB0896-676 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2arq SERPINB2 human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh 1.85Å AUTH D.A.DI GIUSTO,A.P.SUTHERLAND,L.JANKOVA,S.J.HARROP,P.M.CURMI,AUTH 2 G.C.KINGTITL PLASMINOGEN ACTIVATOR INHIBITOR-2 IS HIGHLY TOLERANT TO P8TITL 2 RESIDUE SUBSTITUTION–IMPLICATIONS FOR SERPIN MECHANISTICTITL 3 MODEL AND PREDICTION OF NSSNP ACTIVITIESREF J.MOL.BIOL. V. 353 1069 2005REFN ISSN 0022-2836PMID 16214170DOI 10.1016/J.JMB.2005.09.008 Variant Set Distributions […]