Assessment of Structural Intolerance and Durability
General Structure Information 1sko LAMTOR3 mp1-p14 complex 2.0Å AUTH V.V.LUNIN,C.MUNGER,J.WAGNER,Z.YE,M.CYGLER,M.SACHERTITL THE STRUCTURE OF THE MAP KINASE SCAFFOLD MP1 BOUNDTITL 2 TO ITS PARTNER P14: A COMPLEX WITH A CRITICAL ROLETITL 3 IN ENDOSOMAL MAP KINASE SIGNALINGREF J.BIOL.CHEM. V. 279 23422 2004REFN ISSN 0021-9258PMID 15016825DOI 10.1074/JBC.M401648200 Variant Set Distributions Mapped Variants
General Structure Information 3o2q SYMPK crystal structure of the human symplekin-ssu72-ctd phosphopeptide complex 2.4Å AUTH K.XIANG,T.NAGAIKE,S.XIANG,T.KILIC,M.M.BEH,J.L.MANLEY,L.TONGTITL CRYSTAL STRUCTURE OF THE HUMAN SYMPLEKIN-SSU72-CTDTITL 2 PHOSPHOPEPTIDE COMPLEX.REF NATURE V. 467 729 2010REFN ISSN 0028-0836PMID 20861839DOI 10.1038/NATURE09391 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dm3 PALLD solution structure of the second ig domain of human palladin -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND IG DOMAIN OFTITL 2 HUMAN PALLADINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vsv RHPN2 crystal structure of the pdz domain of human rhophilin-2 1.82Å AUTH A.C.W.PIKE,G.KOCHAN,Z.SUN,N.SHAFQAT,E.S.PILKA,AUTH 2 A.ROOS,J.ELKINS,N.BURGESS-BROWN,J.W.MURRAY,AUTH 3 F.VON DELFT,M.WIKSTROM,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMANTITL 2 RHOPHILIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pnt GRASP crystal structure of the pdz domain of human grasp (grp1) in complex with the c-terminal peptide of the metabotropic glutamate receptor type 1 2.15Å AUTH J.ELKINS,E.PAPAGRIGORIOU,C.COOPER,C.GILEADI,AUTH 2 J.UPPENBERG,J.BRAY,F.VON DELFT,A.C.W.PIKE,AUTH 3 E.UGOCHUKWU,C.UMEANO,O.GILEADI,A.EDWARDS,AUTH 4 C.H.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.A.DOYLE,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN GRASPTITL 2 (GRP1) IN […]
General Structure Information 3w9y DLG1 crystal structure of the human dlg1 guanylate kinase domain 2.2Å AUTH S.MORI,Y.TEZUKA,A.ARAKAWA,N.HANDA,M.SHIROUZU,T.AKIYAMA,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE GUANYLATE KINASE DOMAIN FROM DISCSTITL 2 LARGE HOMOLOG 1 (DLG1/SAP97)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 435 334 2013REFN ISSN 0006-291XPMID 23624197DOI 10.1016/J.BBRC.2013.04.056 Variant Set Distributions Mapped Variants
General Structure Information 1u3b APBA1 auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains -1.0Å AUTH J.-F.LONG,W.FENG,R.WANG,L.-N.CHAN,F.C.IP,J.XIA,AUTH 2 N.Y.IP,M.ZHANGTITL AUTOINHIBITION OF X11/MINT SCAFFOLD PROTEINSTITL 2 REVEALED BY THE CLOSED CONFORMATION OF THE PDZTITL 3 TANDEMREF NAT.STRUCT.MOL.BIOL. V. 12 722 2005REFN ISSN 1545-9993PMID 16007100DOI 10.1038/NSMB958 Variant Set Distributions […]
General Structure Information 3p4f WDR5 structural and biochemical insights into mll1 core complex assembly and regulation. 2.35Å AUTH V.AVDIC,P.ZHANG,S.LANOUETTE,A.GROULX,V.TREMBLAY,J.BRUNZELLE,AUTH 2 J.-F.COUTURETITL STRUCTURAL AND BIOCHEMICAL INSIGHTS INTO MLL1 CORE COMPLEXTITL 2 ASSEMBLY.REF STRUCTURE V. 19 101 2011REFN ISSN 0969-2126PMID 21220120DOI 10.1016/J.STR.2010.09.022 Variant Set Distributions Mapped Variants
General Structure Information 1u3b APBA1 auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains -1.0Å AUTH J.-F.LONG,W.FENG,R.WANG,L.-N.CHAN,F.C.IP,J.XIA,AUTH 2 N.Y.IP,M.ZHANGTITL AUTOINHIBITION OF X11/MINT SCAFFOLD PROTEINSTITL 2 REVEALED BY THE CLOSED CONFORMATION OF THE PDZTITL 3 TANDEMREF NAT.STRUCT.MOL.BIOL. V. 12 722 2005REFN ISSN 1545-9993PMID 16007100DOI 10.1038/NSMB958 Variant Set Distributions […]
General Structure Information 3p4f WDR5 structural and biochemical insights into mll1 core complex assembly and regulation. 2.35Å AUTH V.AVDIC,P.ZHANG,S.LANOUETTE,A.GROULX,V.TREMBLAY,J.BRUNZELLE,AUTH 2 J.-F.COUTURETITL STRUCTURAL AND BIOCHEMICAL INSIGHTS INTO MLL1 CORE COMPLEXTITL 2 ASSEMBLY.REF STRUCTURE V. 19 101 2011REFN ISSN 0969-2126PMID 21220120DOI 10.1016/J.STR.2010.09.022 Variant Set Distributions Mapped Variants