Assessment of Structural Intolerance and Durability
General Structure Information 3evi PDCL2 crystal structure of the thioredoxin-fold domain of human phosducin- like protein 2 2.7Å AUTH X.LOU,R.BAO,C.Z.ZHOU,Y.CHENTITL STRUCTURE OF THE THIOREDOXIN-FOLD DOMAIN OF HUMANTITL 2 PHOSDUCIN-LIKE PROTEIN 2REF ACTA CRYSTALLOGR.,SECT.F V. 65 67 2009REFN ESSN 1744-3091PMID 19193988DOI 10.1107/S1744309108037342 Variant Set Distributions Mapped Variants
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 3v33 ZC3H12A crystal structure of mcpip1 conserved domain with zinc-finger motif 2.0Å AUTH J.XU,W.PENG,Y.SUN,X.WANG,Y.XU,X.LI,G.GAO,Z.RAOTITL STRUCTURAL STUDY OF MCPIP1 N-TERMINAL CONSERVED DOMAINTITL 2 REVEALS A PIN-LIKE RNASEREF NUCLEIC ACIDS RES. V. 40 6957 2012REFN ISSN 0305-1048PMID 22561375DOI 10.1093/NAR/GKS359 Variant Set Distributions Mapped Variants
General Structure Information 2yrb RPGRIP1L solution structure of the first c2 domain from human kiaa1005 protein -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN FROMTITL 2 HUMAN KIAA1005 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ep6 MCTP2 solution structure of the second c2 domain from human mctp2 protein -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND C2 DOMAIN FROMTITL 2 HUMAN MCTP2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1khu SMAD1 smad1 crystal structure reveals the details of bmp signaling pathway 2.5Å AUTH B.Y.QIN,B.M.CHACKO,S.S.LAM,M.P.DE CAESTECKER,AUTH 2 J.J.CORREIA,K.LINTITL STRUCTURAL BASIS OF SMAD1 ACTIVATION BY RECEPTORTITL 2 KINASE PHOSPHORYLATION.REF MOL.CELL V. 8 1303 2001REFN ISSN 1097-2765PMID 11779505DOI 10.1016/S1097-2765(01)00417-8 Variant Set Distributions Mapped Variants
General Structure Information 3b9c LGALSL crystal structure of human grp crd 1.9Å AUTH D.ZHOU,H.GE,J.SUN,Y.GAO,M.TENG,L.NIUTITL CRYSTAL STRUCTURE OF THE C-TERMINAL CONSERVEDTITL 2 DOMAIN OF HUMAN GRP, A GALECTIN-RELATED PROTEIN,TITL 3 REVEALS A FUNCTION MODE DIFFERENT FROM THOSE OFTITL 4 GALECTINS.REF PROTEINS V. 71 1582 2008REFN ISSN 0887-3585PMID 18320588DOI 10.1002/PROT.22003 Variant Set Distributions Mapped Variants
General Structure Information 1fpz CDKN3 crystal structure analysis of kinase associated phosphatase (kap) with a substitution of the catalytic site cysteine (cys140) to a serine 2.0Å AUTH H.SONG,N.HANLON,N.R.BROWN,M.E.NOBLE,L.N.JOHNSON,AUTH 2 D.BARFORDTITL PHOSPHOPROTEIN-PROTEIN INTERACTIONS REVEALED BYTITL 2 THE CRYSTAL STRUCTURE OF KINASE-ASSOCIATEDTITL 3 PHOSPHATASE IN COMPLEX WITH PHOSPHOCDK2.REF MOL.CELL V. 7 615 2001REFN ISSN 1097-2765PMID 11463386DOI 10.1016/S1097-2765(01)00208-8 […]
General Structure Information 2edr OBSCN solution structure of the ig-like domain (3361-3449) of human obscurin -1.0Å AUTH C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IG-LIKE DOMAINTITL 2 (3361-3449) OF HUMAN OBSCURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2v7c NR1D2 crystal structure of rev-erb beta 2.4Å AUTH E.-J.WOO,D.G.JEONG,M.-Y.LIM,S.J.KIM,K.-J.KIM,AUTH 2 S.-M.YOON,B.-C.PARK,S.E.RYUTITL STRUCTURAL INSIGHT INTO THE CONSTITUTIVETITL 2 REPRESSION FUNCTION OF THE NUCLEAR RECEPTORTITL 3 REV-ERBBETAREF J.MOL.BIOL. V. 373 735 2007REFN ISSN 0022-2836PMID 17870090DOI 10.1016/J.JMB.2007.08.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants