Assessment of Structural Intolerance and Durability
General Structure Information 4nh3 DICER1 structure of human dicer platform-paz-connector helix cassette in complex with 13-mer sirna having 5-pu and uu-3 ends (2.6 angstrom resolution) 2.62Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,J.E.PARK,I.HEO,V.N.KIM,D.J.PATELTITL A PHOSPHATE-BINDING POCKET WITHIN THE PLATFORM-PAZ-CONNECTORTITL 2 HELIX CASSETTE OF HUMAN DICER.REF MOL.CELL V. 53 606 2014REFN ISSN 1097-2765PMID 24486018DOI 10.1016/J.MOLCEL.2014.01.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2hky RNASE7 nmr solution structure of human rnase 7 -1.0Å AUTH Y.C.HUANG,Y.M.LIN,T.W.CHANG,S.J.WU,Y.S.LEE,AUTH 2 M.D.CHANG,C.CHEN,S.H.WU,Y.D.LIAOTITL THE FLEXIBLE AND CLUSTERED LYSINE RESIDUES OFTITL 2 HUMAN RIBONUCLEASE 7 ARE CRITICAL FOR MEMBRANETITL 3 PERMEABILITY AND ANTIMICROBIAL ACTIVITY.REF J.BIOL.CHEM. V. 282 4626 2007REFN ISSN 0021-9258PMID 17150966DOI 10.1074/JBC.M607321200 Variant Set Distributions Mapped Variants
General Structure Information 3u1k PNPT1 crystal structure of human pnpase 2.13Å AUTH C.L.LIN,Y.-T.WANG,W.-Z.YANG,Y.-Y.HSIAO,H.S.YUANTITL CRYSTAL STRUCTURE OF HUMAN POLYNUCLEOTIDE PHOSPHORYLASE:TITL 2 INSIGHTS INTO ITS DOMAIN FUNCTION IN RNA BINDING ANDTITL 3 DEGRADATIONREF NUCLEIC ACIDS RES. V. 40 4146 2012REFN ISSN 0305-1048PMID 22210891DOI 10.1093/NAR/GKR1281 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3v33 ZC3H12A crystal structure of mcpip1 conserved domain with zinc-finger motif 2.0Å AUTH J.XU,W.PENG,Y.SUN,X.WANG,Y.XU,X.LI,G.GAO,Z.RAOTITL STRUCTURAL STUDY OF MCPIP1 N-TERMINAL CONSERVED DOMAINTITL 2 REVEALS A PIN-LIKE RNASEREF NUCLEIC ACIDS RES. V. 40 6957 2012REFN ISSN 0305-1048PMID 22561375DOI 10.1093/NAR/GKS359 Variant Set Distributions Mapped Variants
General Structure Information 3puf RNASEH2B crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]