Assessment of Structural Intolerance and Durability
General Structure Information 2yt4 DGCR8 crystal structure of human dgcr8 core 2.6Å AUTH S.Y.SOHN,W.J.BAE,J.J.KIM,K.H.YEOM,V.N.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN DGCR8 COREREF NAT.STRUCT.MOL.BIOL. V. 14 847 2007REFN ISSN 1545-9993PMID 17704815DOI 10.1038/NSMB1294 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hh2 KHSRP solution structure of the fourth kh domain of ksrp -1.0Å AUTH M.F.GARCIA-MAYORAL,D.HOLLINGWORTH,L.MASINO,AUTH 2 I.DIAZ-MORENO,G.KELLY,R.GHERZI,C.F.CHOU,C.Y.CHEN,AUTH 3 A.RAMOSTITL THE STRUCTURE OF THE C-TERMINAL KH DOMAINS OF KSRPTITL 2 REVEALS A NONCANONICAL MOTIF IMPORTANT FOR MRNATITL 3 DEGRADATION.REF STRUCTURE V. 15 485 2007REFN ISSN 0969-2126PMID 17437720DOI 10.1016/J.STR.2007.03.006 Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC8 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Mapped Variants
General Structure Information 2jvz KHSRP solution nmr structure of the second and third kh domains of ksrp -1.0Å AUTH I.DIAZ-MORENO,D.HOLLINGWORTH,M.F.GARCIA-MAYORAL,AUTH 2 G.KELLY,S.MARTIN,C.Y.CHEN,A.RAMOSTITL SOLUTION NMR STRUCTURE OF THE SECOND AND THIRD KHTITL 2 DOMAINS OF KSRPREF TO BE PUBLISHED 2007REFN Variant Set Distributions Mapped Variants
General Structure Information 3sde PSPC1 crystal structure of a paraspeckle-protein heterodimer, pspc1/nono 1.9Å AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3o3i PIWIL1 crystal structure of human hiwi1 paz domain (residues 277-399) in complex with 14-mer rna (12-bp + 2-nt overhang) containing 2-oh at its 3-end 2.8Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,D.J.PATELTITL INAUGURAL ARTICLE: STRUCTURAL BASIS FOR PIRNATITL 2 2-O-METHYLATED 3-END RECOGNITION BY PIWI PAZTITL 3 (PIWI/ARGONAUTE/ZWILLE) DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 903 2011REFN ISSN 0027-8424PMID 21193640DOI […]
General Structure Information 2hwx SMG6 structure of human smg6 e1282c pin domain mutant. 1.9Å AUTH F.GLAVAN,I.BEHM-ANSMANT,E.IZAURRALDE,E.CONTITITL STRUCTURES OF THE PIN DOMAINS OF SMG6 AND SMG5TITL 2 REVEAL A NUCLEASE WITHIN THE MRNA SURVEILLANCETITL 3 COMPLEX.REF EMBO J. V. 25 5117 2006REFN ISSN 0261-4189PMID 17053788DOI 10.1038/SJ.EMBOJ.7601377 Variant Set Distributions Mapped Variants
General Structure Information 1mp1 SRRM1 solution structure of the pwi motif from srm160 -1.0Å AUTH B.R.SZYMCZYNA,J.BOWMAN,S.MCCRACKEN,A.PINEDA-LUCENA,AUTH 2 Y.LU,B.COX,M.LAMBERMON,B.R.GRAVELEY,C.H.ARROWSMITH,AUTH 3 B.J.BLENCOWETITL STRUCTURE AND FUNCTION OF THE PWI MOTIF: A NOVELTITL 2 NUCLEIC ACID-BINDING DOMAIN THAT FACILITATESTITL 3 PRE-MRNA PROCESSING.REF GENES DEV. V. 17 461 2003REFN ISSN 0890-9369PMID 12600940DOI 10.1101/GAD.1060403 Variant Set Distributions Mapped Variants
General Structure Information 3q0q PUM2 crystal structure of the pumilio-homology domain from human pumilio2 in complex with p38alpha nrea 2.0Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants
General Structure Information 4fmw TRMT10A crystal structure of methyltransferase domain of human rna (guanine-9- ) methyltransferase domain containing protein 2 2.0Å AUTH H.ZENG,A.DONG,P.LOPPNAU,W.TEMPEL,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,H.WUTITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN RNATITL 2 (GUANINE-9-) METHYLTRANSFERASE DOMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants