Assessment of Structural Intolerance and Durability
General Structure Information 2dt7 SF3A3 solution structure of the second surp domain of human splicing factor sf3a120 in complex with a fragment of human splicing factor sf3a60 -1.0Å AUTH K.KUWASAKO,F.HE,M.INOUE,A.TANAKA,S.SUGANO,AUTH 2 P.GUENTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SURP DOMAINS AND THETITL 2 SUBUNIT-ASSEMBLY MECHANISM WITHIN THE SPLICINGTITL 3 FACTOR SF3A COMPLEX IN 17S U2 SNRNPREF STRUCTURE […]
General Structure Information 2ha8 TARBP1 methyltransferase domain of human tar (hiv-1) rna binding protein 1 1.6Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,K.BATTAILE,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TAR (HIV-1) RNA BINDING PROTEIN 1 INTITL 3 COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qnd FMR1 crystal structure of the kh1-kh2 domains from human fragile x mental retardation protein 1.9Å AUTH R.VALVERDE,I.POZDNYAKOVA,T.KAJANDER,J.VENKATRAMAN,L.REGANTITL FRAGILE X MENTAL RETARDATION SYNDROME: STRUCTURE OF THETITL 2 KH1-KH2 DOMAINS OF FRAGILE X MENTAL RETARDATION PROTEIN.REF STRUCTURE V. 15 1090 2007REFN ISSN 0969-2126PMID 17850748DOI 10.1016/J.STR.2007.06.022 Variant Set Distributions Mapped Variants
General Structure Information 2cpe EWSR1 solution structure of the rna recognition motif of ewing sarcoma(ews) protein -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OFTITL 2 EWING SARCOMA(EWS) PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC9 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2leb SRSF2 solution structure of human srsf2 (sc35) rrm in complex with 5- uccagu-3 -1.0Å AUTH G.M.DAUBNER,A.CLERY,S.JAYNE,J.STEVENIN,F.H.ALLAINTITL A SYN-ANTI CONFORMATIONAL DIFFERENCE ALLOWS SRSF2 TOTITL 2 RECOGNIZE GUANINES AND CYTOSINES EQUALLY WELL.REF EMBO J. V. 31 162 2012REFN ISSN 0261-4189PMID 22002536DOI 10.1038/EMBOJ.2011.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1x4g TIAL1 solution structure of rrm domain in nucleolysin tiar -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RRM DOMAIN IN NUCLEOLYSINTITL 2 TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1n52 NCBP1 cap binding complex 2.11Å AUTH G.CALERO,K.WILSON,T.LY,J.RIOS-STEINER,J.CLARDY,R.CERIONETITL STRUCTURAL BASIS OF M7GPPPG BINDING TO THE NUCLEARTITL 2 CAP-BINDING PROTEIN COMPLEX.REF NAT.STRUCT.BIOL. V. 9 912 2002REFN ISSN 1072-8368PMID 12434151DOI 10.1038/NSB874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hot IFIT5 crystal structure of full-length human ifit5 with 5`-triphosphate oligoadenine 2.5Å AUTH Y.M.ABBAS,A.PICHLMAIR,M.W.GORNA,G.SUPERTI-FURGA,B.NAGARTITL STRUCTURAL BASIS FOR VIRAL 5-PPP-RNA RECOGNITION BY HUMANTITL 2 IFIT PROTEINS.REF NATURE V. 494 60 2013REFN ISSN 0028-0836PMID 23334420DOI 10.1038/NATURE11783 Variant Set Distributions Mapped Variants
General Structure Information 1xmk ADAR the crystal structure of the zb domain from the rna editing enzyme adar1 0.97Å AUTH A.ATHANASIADIS,D.PLACIDO,S.MAAS,B.A.BROWN II,AUTH 2 K.LOWENHAUPT,A.RICHTITL THE CRYSTAL STRUCTURE OF THE Z[BETA] DOMAIN OF THETITL 2 RNA-EDITING ENZYME ADAR1 REVEALS DISTINCTTITL 3 CONSERVED SURFACES AMONG Z-DOMAINS.REF J.MOL.BIOL. V. 351 496 2005REFN ISSN 0022-2836PMID 16023667DOI 10.1016/J.JMB.2005.06.028 Variant Set […]