General Structure Information 3tso RAB25 structure of the cancer associated rab25 protein in complex with fip2 1.8Å AUTH S.ODA,P.Y.LALL,M.W.MCCAFFREY,A.R.KHANTITL STRUCTURE OF THE CANCER ASSOCIATED RAB25 PROTEIN IN COMPLEXTITL 2 WITH FIP2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hxs RAB28 crystal structure of rab28a gtpase in the inactive (gdp-3p- bound) form 1.1Å AUTH S.H.LEE,Y.LI,R.DOMINGUEZTITL THE CRYSTAL STRUCTURE OF RAB28 GTPASE IN ACTIVETITL 2 AND INACTIVE FORMSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fss RASA1 crystal structure of a ras p21 protein activator (rasa1) from homo sapiens at 2.25 a resolution 2.25Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A RAS P21 PROTEIN ACTIVATOR (RASA1)TITL 2 FROM HOMO SAPIENS AT 2.25 A RESOLUTIONREF TO BE PUBLISHEDREFN […]
General Structure Information 1wer RASA1 ras-gtpase-activating domain of human p120gap 1.6Å AUTH K.SCHEFFZEK,A.LAUTWEIN,W.KABSCH,M.R.AHMADIAN,AUTH 2 A.WITTINGHOFERTITL CRYSTAL STRUCTURE OF THE GTPASE-ACTIVATING DOMAINTITL 2 OF HUMAN P120GAP AND IMPLICATIONS FOR THETITL 3 INTERACTION WITH RAS.REF NATURE V. 384 591 1996REFN ISSN 0028-0836PMID 8955277DOI 10.1038/384591A0 Variant Set Distributions Mapped Variants
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dz8 RAB3B crystal structure of human rab3b gtpase bound with gdp 1.9Å AUTH Y.SHEN,Y.TONG,D.SUKUMAR,W.TEMPEL,P.LOPPNAU,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB3B GTPASE BOUND WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3rap RAP2A the small g protein rap2 in a non catalytic complex with gtp 2.2Å AUTH J.MENETREY,J.CHERFILSTITL STRUCTURE OF THE SMALL G PROTEIN RAP2 IN ATITL 2 NON-CATALYTIC COMPLEX WITH GTP.REF PROTEINS V. 37 465 1999REFN ISSN 0887-3585PMID 10591105DOI 10.1002/(SICI)1097-0134(19991115)37:33.0.CO;2-O Variant Set Distributions Mapped Variants
General Structure Information 4g0n RAF1 crystal structure of wt h-ras-gppnhp bound to the rbd of raf kinase 2.45Å AUTH S.K.FETICS,H.GUTERRES,B.M.KEARNEY,G.BUHRMAN,B.MA,R.NUSSINOV,AUTH 2 C.MATTOSTITL ALLOSTERIC EFFECTS OF THE ONCOGENIC RASQ61L MUTANT ONTITL 2 RAF-RBD.REF STRUCTURE V. 23 505 2015REFN ISSN 0969-2126PMID 25684575DOI 10.1016/J.STR.2014.12.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2lwi HRAS solution structure of h-rast35s mutant protein in complex with kobe2601 -1.0Å AUTH F.SHIMA,Y.YOSHIKAWA,M.YE,M.ARAKI,S.MATSUMOTO,J.LIAO,L.HU,AUTH 2 T.SUGIMOTO,Y.IJIRI,A.TAKEDA,Y.NISHIYAMA,C.SATO,S.MURAOKA,AUTH 3 A.TAMURA,T.OSODA,K.I.TSUDA,T.MIYAKAWA,H.FUKUNISHI,J.SHIMADA,AUTH 4 T.KUMASAKA,M.YAMAMOTO,T.KATAOKATITL IN SILICO DISCOVERY OF SMALL-MOLECULE RAS INHIBITORS THATTITL 2 DISPLAY ANTITUMOR ACTIVITY BY BLOCKING THE RAS-EFFECTORTITL 3 INTERACTION.REF PROC.NATL.ACAD.SCI.USA 2013REFN ESSN 1091-6490PMID 23630290DOI 10.1073/PNAS.1217730110 Variant Set Distributions Ripley’s K Analysis Plots […]