Assessment of Structural Intolerance and Durability
General Structure Information 3gqc REV1 structure of human rev1-dna-dntp ternary complex 2.5Å AUTH M.K.SWAN,R.E.JOHNSON,L.PRAKASH,S.PRAKASH,A.K.AGGARWALTITL STRUCTURE OF THE HUMAN REV1-DNA-DNTP TERNARY COMPLEX.REF J.MOL.BIOL. V. 390 699 2009REFN ISSN 0022-2836PMID 19464298DOI 10.1016/J.JMB.2009.05.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qmc CXXC1 structural basis of selective binding of nonmethylated cpg islands by the cxxc domain of cfp1 2.1Å AUTH C.XU,C.BIAN,R.LAM,A.DONG,J.MINTITL THE STRUCTURAL BASIS FOR SELECTIVE BINDING OF NON-METHYLATEDTITL 2 CPG ISLANDS BY THE CFP1 CXXC DOMAIN.REF NAT COMMUN V. 2 227 2011REFN ESSN 2041-1723PMID 21407193DOI 10.1038/NCOMMS1237 Variant Set Distributions Mapped Variants
General Structure Information 4dhx ENY2 eny2:ganp complex 2.1Å AUTH D.JANI,S.LUTZ,E.HURT,R.A.LASKEY,M.STEWART,V.O.WICKRAMASINGHETITL FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE MAMMALIANTITL 2 TREX-2 COMPLEX THAT LINKS TRANSCRIPTION WITH NUCLEARTITL 3 MESSENGER RNA EXPORT.REF NUCLEIC ACIDS RES. V. 40 4562 2012REFN ISSN 0305-1048PMID 22307388DOI 10.1093/NAR/GKS059 Variant Set Distributions Mapped Variants
General Structure Information 3kjo POT1 crystal structure of hpot1v2-dtrud(agggttag) 1.8Å AUTH J.NANDAKUMAR,E.R.PODELL,T.R.CECHTITL HOW TELOMERIC PROTEIN POT1 AVOIDS RNA TO ACHIEVETITL 2 SPECIFICITY FOR SINGLE-STRANDED DNA.REF PROC.NATL.ACAD.SCI.USA V. 107 651 2010REFN ISSN 0027-8424PMID 20080730DOI 10.1073/PNAS.0911099107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qrf FOXP3 structure of a domain-swapped foxp3 dimer 2.8Å AUTH H.S.BANDUKWALA,Y.WU,M.FEUERER,Y.CHEN,B.BARBOZA,S.GHOSH,AUTH 2 J.C.STROUD,C.BENOIST,D.MATHIS,A.RAO,L.CHENTITL STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER ON DNA AND ITSTITL 2 FUNCTION IN REGULATORY T CELLS.REF IMMUNITY V. 34 479 2011REFN ISSN 1074-7613PMID 21458306DOI 10.1016/J.IMMUNI.2011.02.017 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mvb MTERF crystal structure of a triple rfy mutant of human mterf1 bound to the termination sequence 2.79Å AUTH E.YAKUBOVSKAYA,E.MEJIA,J.BYRNES,E.HAMBARDJIEVA,AUTH 2 M.GARCIA-DIAZTITL HELIX UNWINDING AND BASE FLIPPING ENABLE HUMAN MTERF1 TOTITL 2 TERMINATE MITOCHONDRIAL TRANSCRIPTION.REF CELL(CAMBRIDGE,MASS.) V. 141 982 2010REFN ISSN 0092-8674PMID 20550934DOI 10.1016/J.CELL.2010.05.018 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2lt7 ZBTB33 solution nmr structure of kaiso zinc finger dna binding domain in complex with kaiso binding site dna -1.0Å AUTH B.A.BUCK-KOEHNTOP,R.L.STANFIELD,D.C.EKIERT,AUTH 2 M.A.MARTINEZ-YAMOUT,H.J.DYSON,I.A.WILSON,P.E.WRIGHTTITL MOLECULAR BASIS FOR RECOGNITION OF METHYLATED AND SPECIFICTITL 2 DNA SEQUENCES BY THE ZINC FINGER PROTEIN KAISO.REF PROC.NATL.ACAD.SCI.USA V. 109 15229 2012REFN ISSN 0027-8424PMID 22949637DOI 10.1073/PNAS.1213726109 Variant Set […]
General Structure Information 4ndg APTX human aprataxin (aptx) bound to rna-dna and zn – adenosine vanadate transition state mimic complex 2.54Å AUTH P.TUMBALE,J.S.WILLIAMS,M.J.SCHELLENBERG,T.A.KUNKEL,AUTH 2 R.S.WILLIAMSTITL APRATAXIN RESOLVES ADENYLATED RNA-DNA JUNCTIONS TO MAINTAINTITL 2 GENOME INTEGRITY.REF NATURE V. 506 111 2013REFN ISSN 0028-0836PMID 24362567DOI 10.1038/NATURE12824 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3waa H2AFV the nucleosome containing human h2a.z.2 3.2Å AUTH N.HORIKOSHI,K.SATO,K.SHIMADA,Y.ARIMURA,A.OSAKABE,AUTH 2 H.TACHIWANA,Y.HAYASHI-TAKANAKA,W.IWASAKI,W.KAGAWA,M.HARATA,AUTH 3 H.KIMURA,H.KURUMIZAKATITL STRUCTURAL POLYMORPHISM IN THE L1 LOOP REGIONS OF HUMANTITL 2 H2A.Z.1 AND H2A.Z.2REF ACTA CRYSTALLOGR.,SECT.D V. 69 2431 2013REFN ISSN 0907-4449PMID 24311584DOI 10.1107/S090744491302252X Variant Set Distributions Mapped Variants
General Structure Information 3av1 HIST2H3A the human nucleosome structure containing the histone variant h3.2 2.5Å AUTH H.TACHIWANA,A.OSAKABE,T.SHIGA,Y.MIYA,H.KIMURA,W.KAGAWA,AUTH 2 H.KURUMIZAKATITL STRUCTURES OF HUMAN NUCLEOSOMES CONTAINING MAJOR HISTONE H3TITL 2 VARIANTSREF ACTA CRYSTALLOGR.,SECT.D V. 67 578 2011REFN ISSN 0907-4449PMID 21636898DOI 10.1107/S0907444911014818 Variant Set Distributions Mapped Variants