Assessment of Structural Intolerance and Durability
General Structure Information 3ihr UCHL5 crystal structure of uch37 2.95Å AUTH S.E.BURGIE,C.A.BINGMAN,A.B.SONI,G.N.PHILLIPSTITL STRUCTURAL CHARACTERIZATION OF HUMAN UCH37.REF PROTEINS 2011REFN ESSN 1097-0134PMID 21953935DOI 10.1002/PROT.23147 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z5e PSMG3 crystal structure of proteasome assembling chaperone 3 2.0Å AUTH H.YASHIRODA,T.MIZUSHIMA,K.OKAMOTO,T.KAMEYAMA,AUTH 2 H.HAYASHI,T.KISHIMOTO,S.NIWA,M.KASAHARA,E.KURIMOTO,AUTH 3 E.SAKATA,K.TAKAGI,A.SUZUKI,Y.HIRANO,S.MURATA,AUTH 4 K.KATO,T.YAMANE,K.TANAKATITL CRYSTAL STRUCTURE OF A CHAPERONE COMPLEX THATTITL 2 CONTRIBUTES TO THE ASSEMBLY OF YEAST 20STITL 3 PROTEASOMESREF NAT.STRUCT.MOL.BIOL. V. 15 228 2008REFN ISSN 1545-9993PMID 18278057DOI 10.1038/NSMB.1386 Variant Set Distributions Mapped Variants
General Structure Information 2kr0 ADRM1 a proteasome protein -1.0Å AUTH X.CHEN,B.H.LEE,D.FINLEY,K.J.WALTERSTITL STRUCTURE OF PROTEASOME UBIQUITIN RECEPTOR HRPN13 AND ITSTITL 2 ACTIVATION BY THE SCAFFOLDING PROTEIN HRPN2.REF MOL.CELL V. 38 404 2010REFN ISSN 1097-2765PMID 20471946DOI 10.1016/J.MOLCEL.2010.04.019 Variant Set Distributions Mapped Variants
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants
General Structure Information 1yx6 PSMD4 solution structure of s5a uim-2/ubiquitin complex -1.0Å AUTH Q.WANG,P.YOUNG,K.J.WALTERSTITL STRUCTURE OF S5A BOUND TO MONOUBIQUITIN PROVIDES ATITL 2 MODEL FOR POLYUBIQUITIN RECOGNITIONREF J.MOL.BIOL. V. 348 727 2005REFN ISSN 0022-2836PMID 15826667DOI 10.1016/J.JMB.2005.03.007 Variant Set Distributions Mapped Variants
General Structure Information 2ayn USP14 structure of usp14, a proteasome-associated deubiquitinating enzyme 3.2Å AUTH M.HU,P.LI,L.SONG,P.D.JEFFREY,T.A.CHENOVA,AUTH 2 K.D.WILKINSON,R.E.COHEN,Y.SHITITL STRUCTURE AND MECHANISMS OF THETITL 2 PROTEASOME-ASSOCIATED DEUBIQUITINATING ENZYMETITL 3 USP14.REF EMBO J. V. 24 3747 2005REFN ISSN 0261-4189PMID 16211010DOI 10.1038/SJ.EMBOJ.7600832 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o96 PSMD7 crystal structure of the metal-free dimeric human mov34 mpn domain (residues 1-177) 3.0Å AUTH M.SANCHES,B.S.C.ALVES,N.I.T.ZANCHIN,B.G.GUIMARAESTITL THE CRYSTAL STRUCTURE OF THE HUMAN MOV34 MPN DOMAIN REVEALSTITL 2 A METAL-FREE DIMERREF J.MOL.BIOL. V. 370 846 2007REFN ISSN 0022-2836PMID 17559875DOI 10.1016/J.JMB.2007.04.084 Variant Set Distributions Mapped Variants