Assessment of Structural Intolerance and Durability
General Structure Information 4hhv COL4A3BP crystal structure of ceramide transfer protein pleckstrin homology domain 1.75Å AUTH J.PRASHEK,T.TRUONG,X.YAOTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM THETITL 2 CERAMIDE TRANSFER PROTEIN: IMPLICATIONS FOR CONFORMATIONALTITL 3 CHANGE UPON LIGAND BINDING.REF PLOS ONE V. 8 79590 2013REFN ESSN 1932-6203PMID 24260258DOI 10.1371/JOURNAL.PONE.0079590 Variant Set Distributions Mapped Variants
General Structure Information 1fb8 DAPP1 structure of the pleckstrin homology domain from dapp1/phish 2.4Å AUTH K.M.FERGUSON,J.M.KAVRAN,V.G.SANKARAN,E.FOURNIER,S.J.ISAKOFF,AUTH 2 E.Y.SKOLNIK,M.A.LEMMONTITL STRUCTURAL BASIS FOR DISCRIMINATION OF 3-PHOSPHOINOSITIDESTITL 2 BY PLECKSTRIN HOMOLOGY DOMAINS.REF MOL.CELL V. 6 373 2000REFN ISSN 1097-2765PMID 10983984DOI 10.1016/S1097-2765(00)00037-X Variant Set Distributions Mapped Variants
General Structure Information 2dkp PLEKHA5 solution structure of the ph domain of pleckstrin homology domain-containing protein family a member 5 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PLECKSTRINTITL 2 HOMOLOGY DOMAIN-CONTAINING PROTEIN FAMILY A MEMBERTITL 3 5 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2p0f ARHGAP9 arhgap9 ph domain in complex with ins(1,3,5)p3 1.91Å AUTH D.F.CECCARELLI,I.M.BLASUTIG,M.GOUDREAULT,Z.LI,AUTH 2 J.RUSTON,T.PAWSON,F.SICHERITITL NON-CANONICAL INTERACTION OF PHOSPHOINOSITIDESTITL 2 WITH PLECKSTRIN HOMOLOGY DOMAINS OF TIAM1 ANDTITL 3 ARHGAP9.REF J.BIOL.CHEM. V. 282 13864 2007REFN ISSN 0021-9258PMID 17339315DOI 10.1074/JBC.M700505200 Variant Set Distributions Mapped Variants
General Structure Information 1v88 OSBPL8 solution structure of the pleckstrin homology domain of oxysterol-binding protein-related protein 8 (kiaa1451 protein) -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF OXYSTEROL-BINDING PROTEIN-RELATEDTITL 3 PROTEIN 8 (KIAA1451 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3mb3 PHIP crystal structure of the second bromodomain of pleckstrin homology domain interacting protein (phip) 2.25Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4h8s APPL2 crystal structure of human appl2barph domain 3.5Å AUTH G.J.KING,J.STOCKLI,S.H.HU,B.WINNEN,W.G.DUPREZ,C.C.MEOLI,AUTH 2 J.R.JUNUTULA,R.J.JARROTT,D.E.JAMES,A.E.WHITTEN,J.L.MARTINTITL MEMBRANE CURVATURE PROTEIN EXHIBITS INTERDOMAIN FLEXIBILITYTITL 2 AND BINDS A SMALL GTPASE.REF J.BIOL.CHEM. V. 287 40996 2012REFN ISSN 0021-9258PMID 23055524DOI 10.1074/JBC.M112.349803 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gn1 RAPH1 crystal structure of the ra and ph domains of lamellipodin 2.4Å AUTH Y.C.CHANG,H.ZHANG,M.L.BRENNAN,J.WUTITL CRYSTAL STRUCTURE OF LAMELLIPODIN IMPLICATES DIVERSETITL 2 FUNCTIONS IN ACTIN POLYMERIZATION AND RAS SIGNALING.REF PROTEIN CELL V. 4 211 2013REFN ISSN 1674-800XPMID 23483482DOI 10.1007/S13238-013-2082-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3pp2 ARHGAP27 crystal structure of the pleckstrin homology domain of arhgap27 1.42Å AUTH L.SHEN,W.TEMPEL,Y.TONG,L.NEDYALKOVA,Y.LI,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OFTITL 2 ARHGAP27REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1xdv SOS1 experimentally phased structure of human the son of sevenless protein at 4.1 ang. 4.1Å AUTH H.SONDERMANN,S.M.SOISSON,S.BOYKEVISCH,S.S.YANG,AUTH 2 D.BAR-SAGI,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RASTITL 2 ACTIVATOR SON OF SEVENLESS.REF CELL(CAMBRIDGE,MASS.) V. 119 393 2004REFN ISSN 0092-8674PMID 15507210DOI 10.1016/J.CELL.2004.10.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]