General Structure Information 4fnw ALK crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain 1.75Å AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1zd8 AK3 structure of human adenylate kinase 3 like 1 1.48Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADENYLATE KINASE 3 LIKE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 1h9o PIK3R1 phosphatidylinositol 3-kinase, p85-alpha subunit: c-terminal sh2 domain complexed with a tyr751 phosphopeptide from the pdgf receptor, crystal structure at 1.79 a 1.79Å AUTH R.A.PAUPTIT,C.A.DENNIS,D.J.DERBYSHIRE,A.L.BREEZE,AUTH 2 S.A.WESTON,S.ROWSELL,G.N.MURSHUDOVTITL NMR TRIAL MODELS: EXPERIENCES WITH THE COLICINTITL 2 IMMUNITY PROTEIN IM7 AND THE P85ALPHA C-TERMINALTITL 3 SH2-PEPTIDE COMPLEXREF ACTA CRYSTALLOGR.,SECT.D V. 57 1397 2001REFN […]
General Structure Information 1pbw PIK3R1 structure of bcr-homology (bh) domain 2.0Å AUTH A.MUSACCHIO,L.C.CANTLEY,S.C.HARRISONTITL CRYSTAL STRUCTURE OF THE BREAKPOINT CLUSTERTITL 2 REGION-HOMOLOGY DOMAIN FROM PHOSPHOINOSITIDETITL 3 3-KINASE P85 ALPHA SUBUNIT.REF PROC.NATL.ACAD.SCI.USA V. 93 14373 1996REFN ISSN 0027-8424PMID 8962058DOI 10.1073/PNAS.93.25.14373 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3txo PRKCH pkc eta kinase in complex with a naphthyridine 2.05Å AUTH M.J.VAN EIS,J.P.EVENOU,P.FLOERSHEIM,C.GAUL,S.W.COWAN-JACOB,AUTH 2 L.MONOVICH,G.RUMMEL,W.SCHULER,W.STARK,A.STRAUSS,A.MATT,AUTH 3 E.VANGREVELINGHE,J.WAGNER,N.SOLDERMANNTITL 2,6-NAPHTHYRIDINES AS POTENT AND SELECTIVE INHIBITORS OF THETITL 2 NOVEL PROTEIN KINASE C ISOZYMES.REF BIOORG.MED.CHEM.LETT. V. 21 7367 2011REFN ISSN 0960-894XPMID 22078216DOI 10.1016/J.BMCL.2011.10.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2x2m RET crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor 2.5Å AUTH L.MOLOGNI,R.ROSTAGNO,S.BRUSSOLO,P.P.KNOWLES,AUTH 2 S.KJAER,J.MURRAY-RUST,E.ROSSO,A.ZAMBON,L.SCAPOZZA,AUTH 3 N.Q.MCDONALD,V.LUCCHINI,C.GAMBACORTI-PASSERINITITL SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP ANDTITL 2 CRYSTALLOGRAPHIC STUDIES OF 3-SUBSTITUTED INDOLIN-TITL 3 2-ONE RET INHIBITORS.REF BIOORG.MED.CHEM. V. 18 1482 2010REFN ISSN 0968-0896PMID 20117004DOI 10.1016/J.BMC.2010.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]