General Structure Information 4lqy ENPP4 crystal structure of human enpp4 with amp 1.54Å AUTH R.A.ALBRIGHT,D.L.ORNSTEIN,W.CAO,W.C.CHANG,D.ROBERT,M.TEHAN,AUTH 2 D.HOYER,L.LIU,P.STABACH,G.YANG,E.M.DE LA CRUZ,D.T.BRADDOCKTITL MOLECULAR BASIS OF PURINERGIC SIGNAL METABOLISM BYTITL 2 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASES 4 AND 1TITL 3 AND IMPLICATIONS IN STROKE.REF J.BIOL.CHEM. V. 289 3294 2014REFN ISSN 0021-9258PMID 24338010DOI 10.1074/JBC.M113.505867 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2zmf PDE10A crystal structure of the c-terminal gaf domain of human phosphodiesterase 10a 2.1Å AUTH N.HANDA,E.MIZOHATA,S.KISHISHITA,M.TOYAMA,S.MORITA,AUTH 2 T.UCHIKUBO-KAMO,R.AKASAKA,K.OMORI,J.KOTERA,T.TERADA,AUTH 3 M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE GAF-B DOMAIN FROM HUMANTITL 2 PHOSPHODIESTERASE 10A COMPLEXED WITH ITS LIGAND, CAMPREF J.BIOL.CHEM. V. 283 19657 2008REFN ISSN 0021-9258PMID 18477562DOI 10.1074/JBC.M800595200 Variant Set Distributions Mapped Variants
General Structure Information 1so2 PDE3B catalytic domain of human phosphodiesterase 3b in complex with a dihydropyridazine inhibitor 2.4Å AUTH G.SCAPIN,S.B.PATEL,C.CHUNG,J.P.VARNERIN,AUTH 2 S.D.EDMONDSON,A.MASTRACCHIO,E.R.PARMEE,S.B.SINGH,AUTH 3 J.W.BECKER,L.H.VAN DER PLOEG,M.R.TOTATITL CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 3B:TITL 2 ATOMIC BASIS FOR SUBSTRATE AND INHIBITORTITL 3 SPECIFICITYREF BIOCHEMISTRY V. 43 6091 2004REFN ISSN 0006-2960PMID 15147193DOI 10.1021/BI049868I Variant Set Distributions Ripley’s K […]
General Structure Information 3g45 PDE4B crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 2.63Å AUTH A.B.BURGIN,O.T.MAGNUSSON,J.SINGH,P.WITTE,AUTH 2 B.L.STAKER,J.M.BJORNSSON,M.THORSTEINSDOTTIR,AUTH 3 S.HRAFNSDOTTIR,T.HAGEN,A.S.KISELYOV,L.J.STEWART,AUTH 4 M.E.GURNEYTITL DESIGN OF PHOSPHODIESTERASE 4D (PDE4D) ALLOSTERICTITL 2 MODULATORS FOR ENHANCING COGNITION WITH IMPROVEDTITL 3 SAFETY.REF NAT.BIOTECHNOL. V. 28 63 2010REFN ISSN 1087-0156PMID 20037581DOI 10.1038/NBT.1598 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1so2 PDE3B catalytic domain of human phosphodiesterase 3b in complex with a dihydropyridazine inhibitor 2.4Å AUTH G.SCAPIN,S.B.PATEL,C.CHUNG,J.P.VARNERIN,AUTH 2 S.D.EDMONDSON,A.MASTRACCHIO,E.R.PARMEE,S.B.SINGH,AUTH 3 J.W.BECKER,L.H.VAN DER PLOEG,M.R.TOTATITL CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 3B:TITL 2 ATOMIC BASIS FOR SUBSTRATE AND INHIBITORTITL 3 SPECIFICITYREF BIOCHEMISTRY V. 43 6091 2004REFN ISSN 0006-2960PMID 15147193DOI 10.1021/BI049868I Variant Set Distributions Ripley’s K […]
General Structure Information 3g45 PDE4B crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 2.63Å AUTH A.B.BURGIN,O.T.MAGNUSSON,J.SINGH,P.WITTE,AUTH 2 B.L.STAKER,J.M.BJORNSSON,M.THORSTEINSDOTTIR,AUTH 3 S.HRAFNSDOTTIR,T.HAGEN,A.S.KISELYOV,L.J.STEWART,AUTH 4 M.E.GURNEYTITL DESIGN OF PHOSPHODIESTERASE 4D (PDE4D) ALLOSTERICTITL 2 MODULATORS FOR ENHANCING COGNITION WITH IMPROVEDTITL 3 SAFETY.REF NAT.BIOTECHNOL. V. 28 63 2010REFN ISSN 1087-0156PMID 20037581DOI 10.1038/NBT.1598 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2rnf RNASE4 x-ray crystal structure of human ribonuclease 4 in complex with d(up) 2.4Å AUTH S.S.TERZYAN,R.PERACAULA,R.DE LLORENS,Y.TSUSHIMA,AUTH 2 H.YAMADA,M.SENO,F.X.GOMIS-RUTH,M.COLLTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMAN RNASE 4,TITL 2 UNLIGANDED AND COMPLEXED WITH D(UP), REVEALS THETITL 3 BASIS FOR ITS URIDINE SELECTIVITY.REF J.MOL.BIOL. V. 285 205 1999REFN ISSN 0022-2836PMID 9878400DOI 10.1006/JMBI.1998.2288 Variant Set Distributions […]
General Structure Information 3ibj PDE2A x-ray structure of pde2a 3.02Å AUTH J.PANDIT,M.D.FORMAN,K.F.FENNELL,K.S.DILLMAN,F.S.MENNITITITL MECHANISM FOR THE ALLOSTERIC REGULATION OF PHOSPHODIESTERASETITL 2 2A DEDUCED FROM THE X-RAY STRUCTURE OF A NEAR FULL-LENGTHTITL 3 CONSTRUCT.REF PROC.NATL.ACAD.SCI.USA V. 106 18225 2009REFN ISSN 0027-8424PMID 19828435DOI 10.1073/PNAS.0907635106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants