Assessment of Structural Intolerance and Durability
General Structure Information 1rpm PTPRM human receptor protein tyrosine phosphatase mu, domain 1 2.3Å AUTH K.M.HOFFMANN,N.K.TONKS,D.BARFORDTITL THE CRYSTAL STRUCTURE OF DOMAIN 1 OF RECEPTORTITL 2 PROTEIN-TYROSINE PHOSPHATASE MU.REF J.BIOL.CHEM. V. 272 27505 1997REFN ISSN 0021-9258PMID 9346878DOI 10.1074/JBC.272.44.27505 Variant Set Distributions Mapped Variants
General Structure Information 2vph PTPN4 crystal structure of the human protein tyrosine phosphatase, non-receptor type 4, pdz domain 1.9Å AUTH A.K.ROOS,J.WANG,N.BURGESS-BROWN,J.M.ELKINS,K.KAVANAGH,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,F.VON DELFT,C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE, NON-RECEPTOR TYPE 4, PDZ DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hc2 PTPRB engineered protein tyrosine phosphatase beta catalytic domain 1.4Å AUTH A.G.EVDOKIMOV,M.POKROSS,R.WALTER,M.MEKEL,B.COX,AUTH 2 C.LI,R.BECHARD,F.GENBAUFFE,R.ANDREWS,C.DIVEN,AUTH 3 B.HOWARD,V.RASTOGI,J.GRAY,M.MAIER,K.G.PETERSTITL ENGINEERING THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 TYROSINE PHOSPHATASE BETA FOR STRUCTURE-BASED DRUGTITL 3 DISCOVERY.REF ACTA CRYSTALLOGR.,SECT.D V. 62 1435 2006REFN ISSN 0907-4449PMID 17139078DOI 10.1107/S0907444906037784 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ps5 PTPN6 crystal structure of the full-length human protein tyrosine phosphatase shp-1 3.1Å AUTH W.WANG,L.LIU,X.SONG,Y.MO,C.KOMMA,H.D.BELLAMY,Z.J.ZHAO,AUTH 2 G.W.ZHOUTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASETITL 2 SHP-1 IN THE OPEN CONFORMATION.REF J.CELL.BIOCHEM. V. 112 2062 2011REFN ISSN 0730-2312PMID 21465528DOI 10.1002/JCB.23125 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3n8i ACP1 crystal structure of the a isoform of human cytoplasmic protein tyrosine phosphatase (hcptp-a) in complex with 1-naphtylacetic acid 1.5Å AUTH K.T.HOMAN,D.BALASUBRAMANIAM,C.V.STAUFFACHERTITL STRUCTURAL CHARACTERIZATION OF A SECONDARY BINDING SITE ONTITL 2 LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1c25 CDC25A human cdc25a catalytic domain 2.3Å AUTH E.B.FAUMAN,J.P.COGSWELL,B.LOVEJOY,W.J.ROCQUE,AUTH 2 W.HOLMES,V.G.MONTANA,H.PIWNICA-WORMS,M.J.RINK,AUTH 3 M.A.SAPERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THETITL 2 HUMAN CELL CYCLE CONTROL PHOSPHATASE, CDC25A.REF CELL(CAMBRIDGE,MASS.) V. 93 617 1998REFN ISSN 0092-8674PMID 9604936DOI 10.1016/S0092-8674(00)81190-3 Variant Set Distributions Mapped Variants
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jxf PTPRZ1 ca-like domain of human ptprz 2.0Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jjd PTPRE protein tyrosine phosphatase, receptor type, e isoform 3.2Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1awb IMPA1 human myo-inositol monophosphatase in complex with d- inositol-1-phosphate and calcium 2.5Å AUTH A.J.GANZHORN,J.-M.RONDEAUTITL STRUCTURE OF AN ENZYME-SUBSTRATE COMPLEX AND THETITL 2 CATALYTIC MECHANISM OF HUMAN BRAIN MYO-INOSITOLTITL 3 MONOPHOSPHATASEREF PROTEIN ENG. V. 10 61 1997REFN ISSN 0269-2139 Variant Set Distributions Mapped Variants