Assessment of Structural Intolerance and Durability
General Structure Information 3rk2 SNAP25 truncated snare complex 2.2Å AUTH D.KUMMEL,S.S.KRISHNAKUMAR,D.T.RADOFF,F.LI,C.G.GIRAUDO,AUTH 2 F.PINCET,J.E.ROTHMAN,K.M.REINISCHTITL COMPLEXIN CROSS-LINKS PREFUSION SNARES INTO A ZIGZAG ARRAY.REF NAT.STRUCT.MOL.BIOL. V. 18 927 2011REFN ISSN 1545-9993PMID 21785414DOI 10.1038/NSMB.2101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rk2 SNAP25 truncated snare complex 2.2Å AUTH D.KUMMEL,S.S.KRISHNAKUMAR,D.T.RADOFF,F.LI,C.G.GIRAUDO,AUTH 2 F.PINCET,J.E.ROTHMAN,K.M.REINISCHTITL COMPLEXIN CROSS-LINKS PREFUSION SNARES INTO A ZIGZAG ARRAY.REF NAT.STRUCT.MOL.BIOL. V. 18 927 2011REFN ISSN 1545-9993PMID 21785414DOI 10.1038/NSMB.2101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ywh PLAUR crystal structure of urokinase plasminogen activator receptor 2.7Å AUTH P.LLINAS,M.H.LE DU,H.GARDSVOLL,K.DANO,M.PLOUG,B.GILQUIN,AUTH 2 E.A.STURA,A.MENEZTITL CRYSTAL STRUCTURE OF THE HUMAN UROKINASE PLASMINOGENTITL 2 ACTIVATOR RECEPTOR BOUND TO AN ANTAGONIST PEPTIDEREF EMBO J. V. 24 1655 2005REFN ISSN 0261-4189PMID 15861141DOI 10.1038/SJ.EMBOJ.7600635 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2okk GAD2 the x-ray crystal structure of the 65kda isoform of glutamic acid decarboxylase (gad65) 2.3Å AUTH G.FENALTI,R.H.LAW,A.M.BUCKLE,C.LANGENDORF,K.TUCK,C.J.ROSADO,AUTH 2 N.G.FAUX,K.MAHMOOD,C.S.HAMPE,J.P.BANGA,M.WILCE,AUTH 3 J.SCHMIDBERGER,J.ROSSJOHN,O.EL-KABBANI,R.N.PIKE,A.I.SMITH,AUTH 4 I.R.MACKAY,M.J.ROWLEY,J.C.WHISSTOCKTITL GABA PRODUCTION BY GLUTAMIC ACID DECARBOXYLASE IS REGULATEDTITL 2 BY A DYNAMIC CATALYTIC LOOP.REF NAT.STRUCT.MOL.BIOL. V. 14 280 2007REFN ISSN 1545-9993PMID 17384644DOI 10.1038/NSMB1228 Variant Set Distributions Ripley’s K […]
General Structure Information 2aze E2F1 structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer 2.55Å AUTH S.M.RUBIN,A.L.GALL,N.ZHENG,N.P.PAVLETICHTITL STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TOTITL 2 E2F1-DP1: A MECHANISM FOR PHOSPHORYLATION-INDUCEDTITL 3 E2F RELEASE.REF CELL(CAMBRIDGE,MASS.) V. 123 1093 2005REFN ISSN 0092-8674PMID 16360038DOI 10.1016/J.CELL.2005.09.044 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3q90 G3BP1 crystal structure of the ntf2 domain of ras gtpase-activating protein- binding protein 1 1.7Å AUTH M.WELIN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NTF2 DOMAIN OF RASTITL 2 GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3gwx PPARD molecular recognition of fatty acids by peroxisome proliferator-activated receptors 2.4Å AUTH H.E.XU,M.H.LAMBERT,V.G.MONTANA,D.J.PARKS,AUTH 2 S.G.BLANCHARD,P.J.BROWN,D.D.STERNBACH,J.M.LEHMANN,AUTH 3 G.B.WISELY,T.M.WILLSON,S.A.KLIEWER,M.V.MILBURNTITL MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOMETITL 2 PROLIFERATOR-ACTIVATED RECEPTORS.REF MOL.CELL V. 3 397 1999REFN ISSN 1097-2765PMID 10198642DOI 10.1016/S1097-2765(00)80467-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xu7 RBBP4 structural basis for rbap48 binding to fog-1 1.9Å AUTH S.LEJON,S.Y.THONG,A.MURTHY,S.ALQARNI,N.V.MURZINA,G.A.BLOBEL,AUTH 2 E.D.LAUE,J.P.MACKAYTITL INSIGHTS INTO ASSOCIATION OF THE NURD COMPLEX WITH FOG-1TITL 2 FROM THE CRYSTAL STRUCTURE OF AN RBAP48-FOG- 1 COMPLEX.REF J.BIOL.CHEM. V. 286 1196 2011REFN ISSN 0021-9258PMID 21047798DOI 10.1074/JBC.M110.195842 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 4kx9 ENPEP crystal structure of human aminopeptidase a complexed with arginine 2.25Å AUTH Y.YANG,C.LIU,Y.L.LIN,F.LITITL STRUCTURAL INSIGHTS INTO CENTRAL HYPERTENSION REGULATION BYTITL 2 HUMAN AMINOPEPTIDASE A.REF J.BIOL.CHEM. V. 288 25638 2013REFN ISSN 0021-9258PMID 23888046DOI 10.1074/JBC.M113.494955 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants