Assessment of Structural Intolerance and Durability
General Structure Information 3kuc RAP1A complex of rap1a(e30d/k31e)gdp with rafrbd(a85k/n71r) 1.92Å AUTH D.FILCHTINSKI,O.SHARABI,A.RUPPEL,I.R.VETTER,C.HERRMANN,AUTH 2 J.M.SHIFMANTITL WHAT MAKES RAS AN EFFICIENT MOLECULAR SWITCH: ATITL 2 COMPUTATIONAL, BIOPHYSICAL, AND STRUCTURAL STUDY OF RAS-GDPTITL 3 INTERACTIONS WITH MUTANTS OF RAF.REF J.MOL.BIOL. V. 399 422 2010REFN ISSN 0022-2836PMID 20361980DOI 10.1016/J.JMB.2010.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4drz RAB14 crystal structure of human rab14 2.3Å AUTH J.WANG,W.TEMPEL,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 2 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c6b MDM2 solution structure of the c4 zinc-finger domain of hdm2 -1.0Å AUTH G.W.YU,M.D.ALLEN,A.ANDREEVA,A.R.FERSHT,M.BYCROFTTITL SOLUTION STRUCTURE OF THE C4 ZINC FINGER DOMAIN OFTITL 2 HDM2.REF PROTEIN SCI. V. 15 384 2006REFN ISSN 0961-8368PMID 16385008DOI 10.1110/PS.051927306 Variant Set Distributions Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kuc RAP1A complex of rap1a(e30d/k31e)gdp with rafrbd(a85k/n71r) 1.92Å AUTH D.FILCHTINSKI,O.SHARABI,A.RUPPEL,I.R.VETTER,C.HERRMANN,AUTH 2 J.M.SHIFMANTITL WHAT MAKES RAS AN EFFICIENT MOLECULAR SWITCH: ATITL 2 COMPUTATIONAL, BIOPHYSICAL, AND STRUCTURAL STUDY OF RAS-GDPTITL 3 INTERACTIONS WITH MUTANTS OF RAF.REF J.MOL.BIOL. V. 399 422 2010REFN ISSN 0022-2836PMID 20361980DOI 10.1016/J.JMB.2010.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4drz RAB14 crystal structure of human rab14 2.3Å AUTH J.WANG,W.TEMPEL,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 2 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c6b MDM2 solution structure of the c4 zinc-finger domain of hdm2 -1.0Å AUTH G.W.YU,M.D.ALLEN,A.ANDREEVA,A.R.FERSHT,M.BYCROFTTITL SOLUTION STRUCTURE OF THE C4 ZINC FINGER DOMAIN OFTITL 2 HDM2.REF PROTEIN SCI. V. 15 384 2006REFN ISSN 0961-8368PMID 16385008DOI 10.1110/PS.051927306 Variant Set Distributions Mapped Variants
General Structure Information 1nkp MAX crystal structure of myc-max recognizing dna 1.8Å AUTH S.K.NAIR,S.K.BURLEYTITL X-RAY STRUCTURES OF MYC-MAX AND MAD-MAXTITL 2 RECOGNIZING DNA: MOLECULAR BASES OF REGULATION BYTITL 3 PROTO-ONCOGENIC TRANSCRIPTION FACTORSREF CELL(CAMBRIDGE,MASS.) V. 112 193 2003REFN ISSN 0092-8674PMID 12553908DOI 10.1016/S0092-8674(02)01284-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2lqn CRKL solution structure of crkl -1.0Å AUTH W.JANKOWSKI,T.SALEH,M.T.PAI,G.SRIRAM,R.B.BIRGE,C.G.KALODIMOSTITL DOMAIN ORGANIZATION DIFFERENCES EXPLAIN BCR-ABLS PREFERENCETITL 2 FOR CRKL OVER CRKII.REF NAT.CHEM.BIOL. V. 8 590 2012REFN ISSN 1552-4450PMID 22581121DOI 10.1038/NCHEMBIO.954 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants