Assessment of Structural Intolerance and Durability
General Structure Information 3odx ARHGEF1 crystal structure of an n-terminally truncated linker-dh/ph domains of p115-rhogef 3.2Å AUTH Z.CHEN,L.GUO,S.R.SPRANG,P.C.STERNWEISTITL MODULATION OF A GEF SWITCH: AUTOINHIBITION OF THE INTRINSICTITL 2 GUANINE NUCLEOTIDE EXCHANGE ACTIVITY OF P115-RHOREFREF PROTEIN SCI. V. 20 107 2011REFN ISSN 0961-8368 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2lbc USP13 solution structure of tandem uba of usp13 -1.0Å AUTH Y.ZHANG,C.ZHOU,Z.ZHOU,A.SONG,H.HUTITL DOMAIN ANALYSIS REVEALS THAT A DEUBIQUITINATING ENZYME USP13TITL 2 PERFORMS NON-ACTIVATING CATALYSIS FOR LYS63-LINKEDTITL 3 POLYUBIQUITIN.REF PLOS ONE V. 6 29362 2011REFN ESSN 1932-6203PMID 22216260DOI 10.1371/JOURNAL.PONE.0029362 Variant Set Distributions Mapped Variants
General Structure Information 3c9q WDYHV1 crystal structure of the uncharacterized human protein c8orf32 with bound peptide 1.5Å AUTH E.BITTO,C.A.BINGMAN,J.G.MCCOY,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE UNCHARACTERIZED HUMAN PROTEINTITL 2 C8ORF32 WITH BOUND PEPTIDE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 2nms CD300LF the crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells irem-1 2.6Å AUTH J.A.MARQUEZ,E.GALFRE,F.DUPEUX,D.FLOT,O.MORAN,AUTH 2 N.DIMASITITL THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAINTITL 2 OF THE INHIBITOR RECEPTOR EXPRESSED ON MYELOIDTITL 3 CELLS IREM-1.REF J.MOL.BIOL. V. 367 310 2007REFN ISSN 0022-2836PMID 17275839DOI 10.1016/J.JMB.2007.01.011 Variant Set […]
General Structure Information 2vwr LNX2 crystal structure of the second pdz domain of numb-binding protein 2 1.3Å AUTH A.K.ROOS,K.GUO,N.BURGESS-BROWN,W.W.YUE,J.M.ELKINS,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,C.H.ARROWSMITH,AUTH 3 M.WIKSTOM,A.EDWARDS,F.VON DELFT,C.BOUNTRA,D.DOYLE,AUTH 4 U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF THETITL 2 HUMAN NUMB-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4k92 CLASP1 a cryptic tog domain with a distinct architecture underlies clasp- dependent bipolar spindle formation 2.0Å AUTH J.B.LEANO,S.L.ROGERS,K.C.SLEPTITL A CRYPTIC TOG DOMAIN WITH A DISTINCT ARCHITECTURE UNDERLIESTITL 2 CLASP-DEPENDENT BIPOLAR SPINDLE FORMATION.REF STRUCTURE V. 21 939 2013REFN ISSN 0969-2126PMID 23727231DOI 10.1016/J.STR.2013.04.018 Variant Set Distributions Mapped Variants
General Structure Information 2jxx NFATC2IP nmr solution structure of ubiquitin-like domain of nfatc2ip. northeast structural genomics consortium target hr5627 -1.0Å AUTH R.S.DOHERTY,S.DHE-PAGANON,C.FARES,A.LEMAK,C.BUTLER,AUTH 2 S.SRISAILAM,M.KARRA,A.YEE,J.WEIGELT,A.M.EDWARDS,AUTH 3 C.H.ARROWSMITHTITL SOLUTION STRUCTURE OF UBIQUITIN-LIKE DOMAIN OFTITL 2 NFATC2IP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cry KIRREL3 solution structure of the fifth ig-like domain of human kin of irre like 3 -1.0Å AUTH C.KUROSAKI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH IG-LIKE DOMAIN OFTITL 2 HUMAN KIN OF IRRE LIKE 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2enk SLC30A9 solution structure of a putativ dna-binding domain of the humansolute carrier family 30 (zinc transporter) protein -1.0Å AUTH A.K.GORONCY,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF A PUTATIV DNA-BINDING DOMAINTITL 2 OF THE HUMANSOLUTE CARRIER FAMILY 30 (ZINCTITL 3 TRANSPORTER) PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants