Assessment of Structural Intolerance and Durability
General Structure Information 2vjf MDM2 crystal structure of the mdm2-mdmx ring domain heterodimer 2.3Å AUTH K.LINKE,P.D.MACE,C.A.SMITH,D.L.VAUX,J.SILKE,C.L.DAYTITL STRUCTURE OF THE MDM2/MDMX RING DOMAIN HETERODIMERTITL 2 REVEALS DIMERIZATION IS REQUIRED FOR THEIRTITL 3 UBIQUITYLATION IN TRANS.REF CELL DEATH DIFFER. V. 15 841 2008REFN ISSN 1350-9047PMID 18219319DOI 10.1038/SJ.CDD.4402309 Variant Set Distributions Mapped Variants
General Structure Information 3ex7 MAGOH the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kqs SUMO1 phosphorylation of sumo-interacting motif by ck2 enhances daxx sumo binding activity -1.0Å AUTH C.C.CHANG,M.T.NAIK,Y.S.HUANG,J.C.JENG,P.H.LIAO,H.Y.KUO,AUTH 2 C.C.HO,Y.L.HSIEH,C.H.LIN,N.J.HUANG,N.M.NAIK,C.C.KUNG,AUTH 3 S.Y.LIN,R.H.CHEN,K.S.CHANG,T.H.HUANG,H.M.SHIHTITL STRUCTURAL AND FUNCTIONAL ROLES OF DAXX SIM PHOSPHORYLATIONTITL 2 IN SUMO PARALOG-SELECTIVE BINDING AND APOPTOSIS MODULATION.REF MOL.CELL V. 42 62 2011REFN ISSN 1097-2765PMID 21474068DOI 10.1016/J.MOLCEL.2011.02.022 Variant Set Distributions Mapped Variants
General Structure Information 2kwo HIST4H4 solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4J solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4F solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4H solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4C solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2ka4 STAT2 nmr structure of the cbp-taz1/stat2-tad complex -1.0Å AUTH J.M.WOJCIAK,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR RECRUITMENT OF CBP/P300TITL 2 COACTIVATORS BY STAT1 AND STAT2 TRANSACTIVATIONTITL 3 DOMAINSREF EMBO J. V. 28 948 2009REFN ISSN 0261-4189PMID 19214187DOI 10.1038/EMBOJ.2009.30 Variant Set Distributions Mapped Variants
General Structure Information 2kg1 HNRNPF structure of the third qrrm domain of hnrnp f in complex with a agggau g-tract rna -1.0Å AUTH C.DOMINGUEZ,J.F.FISETTE,B.CHABOT,F.H.ALLAINTITL STRUCTURAL BASIS OF G-TRACT RECOGNITION AND ENCAGING BYTITL 2 HNRNP F QUASI-RRMS.REF NAT.STRUCT.MOL.BIOL. V. 17 853 2010REFN ISSN 1545-9993PMID 20526337DOI 10.1038/NSMB.1814 Variant Set Distributions Mapped Variants