Assessment of Structural Intolerance and Durability
General Structure Information 4hb4 RAN crystal structure of crm1 inhibitor leptomycin b in complex with crm1(537dltvk541/glceq)-ran-ranbp1 2.05Å AUTH Q.SUN,Y.P.CARRASCO,Y.HU,X.GUO,H.MIRZAEI,J.MACMILLAN,AUTH 2 Y.M.CHOOKTITL NUCLEAR EXPORT INHIBITION THROUGH COVALENT CONJUGATION ANDTITL 2 HYDROLYSIS OF LEPTOMYCIN B BY CRM1.REF PROC.NATL.ACAD.SCI.USA V. 110 1303 2013REFN ISSN 0027-8424PMID 23297231DOI 10.1073/PNAS.1217203110 Variant Set Distributions Mapped Variants
General Structure Information 3bg0 SEC13 architecture of a coat for the nuclear pore membrane 3.15Å AUTH K.C.HSIA,P.STAVROPOULOS,G.BLOBEL,A.HOELZTITL ARCHITECTURE OF A COAT FOR THE NUCLEAR PORETITL 2 MEMBRANE.REF CELL(CAMBRIDGE,MASS.) V. 131 1313 2007REFN ISSN 0092-8674PMID 18160040DOI 10.1016/J.CELL.2007.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i4r NUP107 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Mapped Variants
General Structure Information 1gy5 NUTF2 d92n,d94n double point mutant of human nuclear transport factor 2 (ntf2) 2.3Å AUTH R.BAYLISS,S.LEUNG,R.BAKER,B.QUIMBY,A.CORBETT,AUTH 2 M.STEWARTTITL STRUCTURAL BASIS FOR THE INTERACTION BETWEEN NTF2TITL 2 AND NUCLEOPORIN FXFG REPEATSREF EMBO J. V. 21 2843 2002REFN ISSN 0261-4189PMID 12065398DOI 10.1093/EMBOJ/CDF305 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2gl8 RXRG human retinoic acid receptor rxr-gamma ligand-binding domain 2.4Å AUTH A.SCHUETZ,J.R.MIN,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN RETINOIC ACID RECEPTORTITL 2 RXR-GAMMA LIGAND-BINDING DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qln ATRX crystal structure of atrx add domain in free state 1.9Å AUTH S.IWASE,B.XIANG,S.GHOSH,T.REN,P.W.LEWIS,J.C.COCHRANE,AUTH 2 C.D.ALLIS,D.J.PICKETTS,D.J.PATEL,H.LI,Y.SHITITL ATRX ADD DOMAIN LINKS AN ATYPICAL HISTONE METHYLATIONTITL 2 RECOGNITION MECHANISM TO HUMAN MENTAL-RETARDATION SYNDROMEREF NAT.STRUCT.MOL.BIOL. V. 18 769 2011REFN ISSN 1545-9993PMID 21666679DOI 10.1038/NSMB.2062 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4nie RORC crystal structure of the orphan nuclear receptor ror(gamma)t ligand- binding domain in complex with small molecule ligand 2.01Å AUTH T.YANG,L.QIAN,Y.B.CHENG,W.CAI,Y.L.MA,L.Q.YANG,Q.Q.WU,AUTH 2 L.A.ORBAND-MILLER,L.ZHOU,M.HUXDORF,W.ZHANG,J.ZHANG,AUTH 3 J.N.XIANG,S.LEUNG,Y.QIU,Z.ZHONG,J.D.ELLIOT,X.C.LIN,Y.H.WANGTITL DISCOVERY OF TERTIARY AMINE AND INDOLE DERIVATIVES AS POTENTTITL 2 ROR-GAMMA-T INVERSE AGONISTSREF ACS MED.CHEM.LETT. 2013REFN ISSN 1948-5875DOI 10.1021/ML4003875 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1rrp RANBP2 structure of the ran-gppnhp-ranbd1 complex 2.96Å AUTH I.R.VETTER,C.NOWAK,T.NISHIMOTO,J.KUHLMANN,AUTH 2 A.WITTINGHOFERTITL STRUCTURE OF A RAN-BINDING DOMAIN COMPLEXED WITHTITL 2 RAN BOUND TO A GTP ANALOGUE: IMPLICATIONS FORTITL 3 NUCLEAR TRANSPORT.REF NATURE V. 398 39 1999REFN ISSN 0028-0836PMID 10078529DOI 10.1038/17969 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1jkw CCNH structure of cyclin mcs2 2.6Å AUTH G.ANDERSEN,A.POTERSZMAN,J.M.EGLY,D.MORAS,AUTH 2 J.C.THIERRYTITL THE CRYSTAL STRUCTURE OF HUMAN CYCLIN H.REF FEBS LETT. V. 397 65 1996REFN ISSN 0014-5793PMID 8941715DOI 10.1016/S0014-5793(96)01143-X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3uio RANBP2 complex between human rangap1-sumo2, ubc9 and the ir1 domain from ranbp2 containing ir2 motif ii 2.6Å AUTH J.R.GAREAU,D.REVERTER,C.D.LIMATITL DETERMINANTS OF SMALL UBIQUITIN-LIKE MODIFIER 1 (SUMO1)TITL 2 PROTEIN SPECIFICITY, E3 LIGASE, AND SUMO-RANGAP1 BINDINGTITL 3 ACTIVITIES OF NUCLEOPORIN RANBP2.REF J.BIOL.CHEM. V. 287 4740 2012REFN ISSN 0021-9258PMID 22194619DOI 10.1074/JBC.M111.321141 Variant Set Distributions […]