Assessment of Structural Intolerance and Durability
General Structure Information 2eoc PARP3 solution structure of the wgr domain from human poly [adp- ribose] polymerase-3 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE WGR DOMAIN FROM HUMANTITL 2 POLY [ADP-RIBOSE] POLYMERASE-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3se2 PARP14 human poly(adp-ribose) polymerase 14 (parp14/artd8) – catalytic domain in complex with 6(5h)-phenanthridinone 2.3Å AUTH E.WAHLBERG,T.KARLBERG,E.KOUZNETSOVA,N.MARKOVA,A.MACCHIARULO,AUTH 2 A.G.THORSELL,E.POL,A.FROSTELL,T.EKBLAD,D.ONCU,B.KULL,AUTH 3 G.M.ROBERTSON,R.PELLICCIARI,H.SCHULER,J.WEIGELTTITL FAMILY-WIDE CHEMICAL PROFILING AND STRUCTURAL ANALYSIS OFTITL 2 PARP AND TANKYRASE INHIBITORS.REF NAT.BIOTECHNOL. V. 30 283 2012REFN ISSN 1087-0156PMID 22343925DOI 10.1038/NBT.2121 Variant Set Distributions Mapped Variants
General Structure Information 2qnk HAAO crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 1.6Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYANTHRANILATETITL 2 3,4-DIOXYGENASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants