Assessment of Structural Intolerance and Durability
General Structure Information 4dzo MAD1L1 structure of human mad1 c-terminal domain reveals its involvement in kinetochore targeting 1.76Å AUTH S.KIM,H.SUN,D.R.TOMCHICK,H.YU,X.LUOTITL STRUCTURE OF HUMAN MAD1 C-TERMINAL DOMAIN REVEALS ITSTITL 2 INVOLVEMENT IN KINETOCHORE TARGETING.REF PROC.NATL.ACAD.SCI.USA V. 109 6549 2012REFN ISSN 0027-8424PMID 22493223DOI 10.1073/PNAS.1118210109 Variant Set Distributions Mapped Variants
General Structure Information 1go4 MAD1L1 crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. 2.05Å AUTH L.SIRONI,M.MAPELLI,S.KNAPP,A.ANTONI,K.T.JEANG,AUTH 2 A.MUSACCHIOTITL CRYSTAL STRUCTURE OF THE TETRAMERIC MAD1-MAD2 CORETITL 2 COMPLEX: IMPLICATIONS OF A SAFETY BELT BINDINGTITL 3 MECHANISM FOR THE SPINDLE CHECKPOINTREF EMBO J. V. 21 2496 2002REFN ISSN 0261-4189PMID 12006501DOI 10.1093/EMBOJ/21.10.2496 […]
General Structure Information 3abd MAD2L2 structure of human rev7 in complex with a human rev3 fragment in a monoclinic crystal 1.9Å AUTH K.HARA,H.HASHIMOTO,Y.MURAKUMO,S.KOBAYASHI,T.KOGAME,S.UNZAI,AUTH 2 S.AKASHI,S.TAKEDA,T.SHIMIZU,M.SATOTITL CRYSTAL STRUCTURE OF HUMAN REV7 IN COMPLEX WITH A HUMAN REV3TITL 2 FRAGMENT AND STRUCTURAL IMPLICATION OF THE INTERACTIONTITL 3 BETWEEN DNA POLYMERASE {ZETA} AND REV1REF J.BIOL.CHEM. V. 285 12299 […]
General Structure Information 3ffl ANAPC7 crystal structure of the n-terminal domain of anaphase-promoting complex subunit 7 2.5Å AUTH D.HAN,K.KIM,Y.KIM,Y.KANG,Y.KIMTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OFTITL 2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4f9b DBF4 human cdc7 kinase in complex with dbf4 and pha767491 2.5Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Mapped Variants
General Structure Information 3l82 FBXO4 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ve7 SPC25 crystal structure of a bonsai version of the human ndc80 complex 2.88Å AUTH C.CIFERRI,S.PASQUALATO,E.SCREPANTI,G.VARETTI,S.SANTAGUIDA,AUTH 2 G.DOS REIS,A.MAIOLICA,J.POLKA,J.G.DE LUCA,P.DE WULF,M.SALEK,AUTH 3 J.RAPPSILBER,C.A.MOORES,E.D.SALMON,A.MUSACCHIOTITL IMPLICATIONS FOR KINETOCHORE-MICROTUBULE ATTACHMENT FROMTITL 2 THE STRUCTURE OF AN ENGINEERED NDC80 COMPLEXREF CELL(CAMBRIDGE,MASS.) V. 133 427 2008REFN ISSN 0092-8674PMID 18455984DOI 10.1016/J.CELL.2008.03.020 Variant Set Distributions Mapped Variants
General Structure Information 3f9y SETD8 structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me1 / adohcy 1.5Å AUTH J.F.COUTURE,L.M.DIRK,J.S.BRUNZELLE,R.L.HOUTZ,R.C.TRIEVELTITL STRUCTURAL ORIGINS FOR THE PRODUCT SPECIFICITY OF SET DOMAINTITL 2 PROTEIN METHYLTRANSFERASES.REF PROC.NATL.ACAD.SCI.USA V. 105 20659 2008REFN ISSN 0027-8424PMID 19088188DOI 10.1073/PNAS.0806712105 Variant Set Distributions Mapped Variants
General Structure Information 3if8 ZWILCH crystal structure of zwilch, a member of the rzz kinetochore complex 2.55Å AUTH F.CIVRIL,A.WEHENKEL,F.M.GIORGI,S.SANTAGUIDA,A.DI FONZO,AUTH 2 G.GRIGOREAN,F.D.CICCARELLI,A.MUSACCHIOTITL STRUCTURAL ANALYSIS OF THE RZZ COMPLEX REVEALS COMMONTITL 2 ANCESTRY WITH MULTISUBUNIT VESICLE TETHERING MACHINERY.REF STRUCTURE V. 18 616 2010REFN ISSN 0969-2126PMID 20462495DOI 10.1016/J.STR.2010.02.014 Variant Set Distributions Mapped Variants