Assessment of Structural Intolerance and Durability
General Structure Information 2q8h PDK1 structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) 2.0Å AUTH M.KATO,J.LI,J.L.CHUANG,D.T.CHUANGTITL DISTINCT STRUCTURAL MECHANISMS FOR INHIBITION OF PYRUVATETITL 2 DEHYDROGENASE KINASE ISOFORMS BY AZD7545, DICHLOROACETATE,TITL 3 AND RADICICOL.REF STRUCTURE V. 15 992 2007REFN ISSN 0969-2126PMID 17683942DOI 10.1016/J.STR.2007.07.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1p32 C1QBP crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein 2.25Å AUTH J.JIANG,Y.ZHANG,A.R.KRAINER,R.M.XUTITL CRYSTAL STRUCTURE OF HUMAN P32, A DOUGHNUT-SHAPEDTITL 2 ACIDIC MITOCHONDRIAL MATRIX PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 96 3572 1999REFN ISSN 0027-8424PMID 10097078DOI 10.1073/PNAS.96.7.3572 Variant Set Distributions Mapped Variants
General Structure Information 2bsk TIMM10 crystal structure of the tim9 tim10 hexameric complex 3.3Å AUTH C.T.WEBB,M.A.GORMAN,M.LAZAROU,M.T.RYAN,J.M.GULBISTITL CRYSTAL STRUCTURE OF THE MITOCHONDRIAL CHAPERONETITL 2 TIM9*10 REVEALS A SIX-BLADED ALPHA-PROPELLER.REF MOL.CELL V. 21 123 2006REFN ISSN 1097-2765PMID 16387659DOI 10.1016/J.MOLCEL.2005.11.010 Variant Set Distributions Mapped Variants
General Structure Information 1p32 C1QBP crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein 2.25Å AUTH J.JIANG,Y.ZHANG,A.R.KRAINER,R.M.XUTITL CRYSTAL STRUCTURE OF HUMAN P32, A DOUGHNUT-SHAPEDTITL 2 ACIDIC MITOCHONDRIAL MATRIX PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 96 3572 1999REFN ISSN 0027-8424PMID 10097078DOI 10.1073/PNAS.96.7.3572 Variant Set Distributions Mapped Variants