General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ha8 TARBP1 methyltransferase domain of human tar (hiv-1) rna binding protein 1 1.6Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,K.BATTAILE,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TAR (HIV-1) RNA BINDING PROTEIN 1 INTITL 3 COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qpw PRDM2 methyltransferase domain of human pr domain-containing protein 2 1.79Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Mapped Variants
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ha8 TARBP1 methyltransferase domain of human tar (hiv-1) rna binding protein 1 1.6Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,K.BATTAILE,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TAR (HIV-1) RNA BINDING PROTEIN 1 INTITL 3 COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2aot HNMT histamine methyltransferase complexed with the antihistamine drug diphenhydramine 1.9Å AUTH J.R.HORTON,K.SAWADA,M.NISHIBORI,X.CHENGTITL STRUCTURAL BASIS FOR INHIBITION OF HISTAMINETITL 2 N-METHYLTRANSFERASE BY DIVERSE DRUGSREF J.MOL.BIOL. V. 353 334 2005REFN ISSN 0022-2836PMID 16168438DOI 10.1016/J.JMB.2005.08.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rod NNMT methyltransferase 2.72Å AUTH Y.PENG,D.SARTINI,V.POZZI,D.WILK,M.EMANUELLI,V.C.YEETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION IN HUMANTITL 2 NICOTINAMIDE N-METHYLTRANSFERASE.REF BIOCHEMISTRY V. 50 7800 2011REFN ISSN 0006-2960PMID 21823666DOI 10.1021/BI2007614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bwy COMT crystal structure of human 108m catechol o- methyltransferase bound with s-adenosylmethionine and inhibitor dinitrocatechol 1.3Å AUTH K.RUTHERFORD,I.LE TRONG,R.E.STENKAMP,W.W.PARSONTITL CRYSTAL STRUCTURES OF HUMAN 108V AND 108M CATECHOLTITL 2 O-METHYLTRANSFERASE.REF J.MOL.BIOL. V. 380 120 2008REFN ISSN 0022-2836PMID 18486144DOI 10.1016/J.JMB.2008.04.040 Variant Set Distributions Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]