Assessment of Structural Intolerance and Durability
General Structure Information 2b6h ARF5 structure of human adp-ribosylation factor 5 1.76Å AUTH A.ATANASSOVA,W.TEMPEL,E.SUNDARAJAN,S.DIMOV,I.SHEHAB,J.LEW,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 2ymk DCD crystal structure of the hexameric anti-microbial peptide channel dermcidin 2.49Å AUTH C.SONG,C.WEICHBRODT,E.S.SALNIKOV,M.DYNOWSKI,B.O.FORSBERG,AUTH 2 B.BECHINGER,C.STEINEM,B.L.DE GROOT,U.ZACHARIAE,K.ZETHTITL CRYSTAL STRUCTURE AND FUNCTIONAL MECHANISM OF A HUMANTITL 2 ANTIMICROBIAL MEMBRANE CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 110 4586 2013REFN ISSN 0027-8424PMID 23426625DOI 10.1073/PNAS.1214739110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1b4r PKD1 pkd domain 1 from human polycystein-1 -1.0Å AUTH M.BYCROFT,A.BATEMAN,J.CLARKE,S.J.HAMILL,R.SANDFORD,AUTH 2 R.L.THOMAS,C.CHOTHIATITL THE STRUCTURE OF A PKD DOMAIN FROM POLYCYSTIN-1:TITL 2 IMPLICATIONS FOR POLYCYSTIC KIDNEY DISEASE.REF EMBO J. V. 18 297 1999REFN ISSN 0261-4189PMID 9889186DOI 10.1093/EMBOJ/18.2.297 Variant Set Distributions Mapped Variants
General Structure Information 4cc1 JAG1 notch ligand, jagged-1, contains an n-terminal c2 domain 2.84Å AUTH C.R.CHILAKURI,D.SHEPPARD,M.X.G.ILAGAN,L.R.HOLT,F.ABBOTT,AUTH 2 S.LIANG,R.KOPAN,P.A.HANDFORD,S.M.LEATITL STRUCTURAL ANALYSIS UNCOVERS LIPID-BINDING PROPERTIES OFTITL 2 NOTCH LIGANDSREF CELL REP. V. 5 861 2013REFN ISSN 2211-1247PMID 24239355DOI 10.1016/J.CELREP.2013.10.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ev8 MPP1 solution structure of the erythroid p55 pdz domain -1.0Å AUTH H.KUSUNOKI,T.KOHNOTITL SOLUTION STRUCTURE OF HUMAN ERYTHROID P55 PDZTITL 2 DOMAINREF PROTEINS V. 64 804 2006REFN ISSN 0887-3585PMID 16741958DOI 10.1002/PROT.21028 Variant Set Distributions Mapped Variants
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3dpr VLDLR human rhinovirus 2 bound to a concatamer of the vldl receptor module v3 3.5Å AUTH J.QUEROL-AUDI,T.KONECSNI,J.POUS,O.CARUGO,I.FITA,N.VERDAGUER,AUTH 2 D.BLAASTITL MINOR GROUP HUMAN RHINOVIRUS-RECEPTOR INTERACTIONS: GEOMETRYTITL 2 OF MULTIMODULAR ATTACHMENT AND BASIS OF RECOGNITIONREF FEBS LETT. V. 583 235 2009REFN ISSN 0014-5793PMID 19073182DOI 10.1016/J.FEBSLET.2008.12.014 Variant Set Distributions Mapped Variants
General Structure Information 4m8n RAP1B crystal structure of plexinc1/rap1b complex 3.29Å AUTH Y.WANG,H.G.PASCOE,C.A.BRAUTIGAM,H.HE,X.ZHANGTITL STRUCTURAL BASIS FOR ACTIVATION AND NON-CANONICAL CATALYSISTITL 2 OF THE RAP GTPASE ACTIVATING PROTEIN DOMAIN OF PLEXIN.REF ELIFE V. 2 01279 2013REFN ESSN 2050-084XPMID 24137545DOI 10.7554/ELIFE.01279 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ney MPP1 crystal structure of the kinase domain of mpp1/p55 2.26Å AUTH Y.SHEN,Y.TONG,N.ZHONG,X.GUAN,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF MPP1/P55REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants