Assessment of Structural Intolerance and Durability
General Structure Information 2lp1 APP the solution nmr structure of the transmembrane c-terminal domain of the amyloid precursor protein (c99) -1.0Å AUTH P.J.BARRETT,Y.SONG,W.D.VAN HORN,E.J.HUSTEDT,J.M.SCHAFER,AUTH 2 A.HADZISELIMOVIC,A.J.BEEL,C.R.SANDERSTITL THE AMYLOID PRECURSOR PROTEIN HAS A FLEXIBLE TRANSMEMBRANETITL 2 DOMAIN AND BINDS CHOLESTEROL.REF SCIENCE V. 336 1168 2012REFN ISSN 0036-8075PMID 22654059DOI 10.1126/SCIENCE.1219988 Variant Set Distributions Mapped Variants
General Structure Information 1hyn SLC4A1 crystal structure of the cytoplasmic domain of human erythrocyte band-3 protein 2.6Å AUTH D.ZHANG,A.KIYATKIN,J.T.BOLIN,P.S.LOWTITL CRYSTALLOGRAPHIC STRUCTURE AND FUNCTIONALTITL 2 INTERPRETATION OF THE CYTOPLASMIC DOMAIN OFTITL 3 ERYTHROCYTE MEMBRANE BAND 3.REF BLOOD V. 96 2925 2000REFN ISSN 0006-4971PMID 11049968 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lej PRNP human prion protein mutant huprp(90-231, m129, v210i) -1.0Å AUTH I.BILJAN,G.ILC,G.GIACHIN,A.RASPADORI,I.ZHUKOV,J.PLAVEC,AUTH 2 G.LEGNAMETITL TOWARD THE MOLECULAR BASIS OF INHERITED PRION DISEASES: NMRTITL 2 STRUCTURE OF THE HUMAN PRION PROTEIN WITH V210I MUTATION.REF J.MOL.BIOL. V. 412 660 2011REFN ISSN 0022-2836PMID 21839748DOI 10.1016/J.JMB.2011.07.067 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n7p RAMP1 crystal structure of the ectodomain complex of the cgrp receptor, a class-b gpcr, reveals the site of drug antagonism 2.8Å AUTH E.TER HAAR,C.M.KOTH,N.ABDUL-MANAN,L.SWENSON,J.T.COLL,AUTH 2 J.A.LIPPKE,C.A.LEPRE,M.GARCIA-GUZMAN,J.M.MOORETITL CRYSTAL STRUCTURE OF THE ECTODOMAIN COMPLEX OF THE CGRPTITL 2 RECEPTOR, A CLASS-B GPCR, REVEALS THE SITE OF DRUGTITL 3 ANTAGONISM.REF STRUCTURE V. 18 1083 […]
General Structure Information 4ihb DYSF x-ray structure of the canonical c2a domain from human dysferlin 2.04Å AUTH K.FUSON,A.RICE,R.MAHLING,A.SNOW,K.NAYAK,P.SHANBHOGUE,AUTH 2 A.G.MEYER,G.M.REDPATH,A.HINDERLITER,S.T.COOPER,R.B.SUTTONTITL ALTERNATE SPLICING OF DYSFERLIN C2A CONFERS CA(2+)-DEPENDENTTITL 2 AND CA(2+)-INDEPENDENT BINDING FOR MEMBRANE REPAIR.REF STRUCTURE V. 22 104 2014REFN ISSN 0969-2126PMID 24239457DOI 10.1016/J.STR.2013.10.001 Variant Set Distributions Mapped Variants
General Structure Information 3ikk VAPB crystal structure analysis of msp domain 2.5Å AUTH J.SHI,S.LUA,J.S.TONG,J.SONGTITL ELIMINATION OF THE NATIVE STRUCTURE AND SOLUBILITY OF THETITL 2 HVAPB MSP DOMAIN BY THE PRO56SER MUTATION THAT CAUSESTITL 3 AMYOTROPHIC LATERAL SCLEROSIS.REF BIOCHEMISTRY V. 49 3887 2010REFN ISSN 0006-2960PMID 20377183DOI 10.1021/BI902057A Variant Set Distributions Mapped Variants
General Structure Information 1zza SNN solution nmr structure of the membrane protein stannin -1.0Å AUTH B.A.BUCK-KOEHNTOP,A.MASCIONI,J.J.BUFFY,G.VEGLIATITL STRUCTURE, DYNAMICS, AND MEMBRANE TOPOLOGY OFTITL 2 STANNIN: A MEDIATOR OF NEURONAL CELL APOPTOSISTITL 3 INDUCED BY TRIMETHYLTIN CHLORIDE.REF J.MOL.BIOL. V. 354 652 2005REFN ISSN 0022-2836PMID 16246365DOI 10.1016/J.JMB.2005.09.038 Variant Set Distributions Mapped Variants
General Structure Information 4cai DYSF structure of inner dysf domain of human dysferlin 2.2Å AUTH A.SULA,A.R.COLE,C.YEATS,C.ORENGO,N.H.KEEPTITL CRYSTAL STRUCTURES OF THE HUMAN DYSFERLIN INNER DYSF DOMAINREF BMC STRUCT.BIOL. V. 14 3 2014REFN ISSN 1472-6807PMID 24438169DOI 10.1186/1472-6807-14-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kng LGR5 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4npj ESYT2 extended-synaptotagmin 2, c2a- and c2b-domains 2.1Å AUTH J.XU,T.BACAJ,A.ZHOU,D.R.TOMCHICK,T.C.SUDHOF,J.RIZOTITL STRUCTURE AND CA(2+)-BINDING PROPERTIES OF THE TANDEM C2TITL 2 DOMAINS OF E-SYT2.REF STRUCTURE V. 22 269 2014REFN ISSN 0969-2126PMID 24373768DOI 10.1016/J.STR.2013.11.011 Variant Set Distributions Mapped Variants