Assessment of Structural Intolerance and Durability
General Structure Information 1ef1 MSN crystal structure of the moesin ferm domain/tail domain complex 1.9Å AUTH M.A.PEARSON,D.RECZEK,A.BRETSCHER,P.A.KARPLUSTITL STRUCTURE OF THE ERM PROTEIN MOESIN REVEALS THE FERM DOMAINTITL 2 FOLD MASKED BY AN EXTENDED ACTIN BINDING TAIL DOMAIN.REF CELL(CAMBRIDGE,MASS.) V. 101 259 2000REFN ISSN 0092-8674PMID 10847681DOI 10.1016/S0092-8674(00)80836-3 Variant Set Distributions Mapped Variants
General Structure Information 1e5w MSN structure of isolated ferm domain and first long helix of moesin 2.7Å AUTH S.D.EDWARDS,N.H.KEEPTITL THE 2.7 A CRYSTAL STRUCTURE OF THE ACTIVATED FERMTITL 2 DOMAIN OF MOESIN: AN ANALYSIS OF STRUCTURALTITL 3 CHANGES ON ACTIVATIONREF BIOCHEMISTRY V. 40 7061 2001REFN ISSN 0006-2960PMID 11401550DOI 10.1021/BI010419H Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3v2w S1PR1 crystal structure of a lipid g protein-coupled receptor at 3.35a 3.35Å AUTH M.A.HANSON,C.B.ROTH,E.JO,M.T.GRIFFITH,F.L.SCOTT,G.REINHART,AUTH 2 H.DESALE,B.CLEMONS,S.M.CAHALAN,S.C.SCHUERER,M.G.SANNA,AUTH 3 G.W.HAN,P.KUHN,H.ROSEN,R.C.STEVENSTITL CRYSTAL STRUCTURE OF A LIPID G PROTEIN-COUPLED RECEPTOR.REF SCIENCE V. 335 851 2012REFN ISSN 0036-8075PMID 22344443DOI 10.1126/SCIENCE.1215904 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k4t VDAC1 solution structure of human vdac-1 in ldao micelles -1.0Å AUTH S.HILLER,R.G.GARCES,T.J.MALIA,V.Y.OREKHOV,AUTH 2 M.COLOMBINI,G.WAGNERTITL SOLUTION STRUCTURE OF THE INTEGRAL HUMAN MEMBRANETITL 2 PROTEIN VDAC-1 IN DETERGENT MICELLES.REF SCIENCE V. 321 1206 2008REFN ISSN 0036-8075PMID 18755977DOI 10.1126/SCIENCE.1161302 Variant Set Distributions Mapped Variants
General Structure Information 4iar HTR1B crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) 2.7Å AUTH C.WANG,Y.JIANG,J.MA,H.WU,D.WACKER,V.KATRITCH,G.W.HAN,W.LIU,AUTH 2 X.P.HUANG,E.VARDY,J.D.MCCORVY,X.GAO,X.E.ZHOU,K.MELCHER,AUTH 3 C.ZHANG,F.BAI,H.YANG,L.YANG,H.JIANG,B.L.ROTH,V.CHEREZOV,AUTH 4 R.C.STEVENS,H.E.XUTITL STRUCTURAL BASIS FOR MOLECULAR RECOGNITION AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 610 2013REFN ISSN 0036-8075PMID 23519210DOI 10.1126/SCIENCE.1232807 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3vw7 F2R crystal structure of human protease-activated receptor 1 (par1) bound with antagonist vorapaxar at 2.2 angstrom 2.2Å AUTH C.ZHANG,Y.SRINIVASAN,D.H.ARLOW,J.J.FUNG,D.PALMER,Y.ZHENG,AUTH 2 H.F.GREEN,A.PANDEY,R.O.DROR,D.E.SHAW,W.I.WEIS,S.R.COUGHLIN,AUTH 3 B.K.KOBILKATITL HIGH-RESOLUTION CRYSTAL STRUCTURE OF HUMANTITL 2 PROTEASE-ACTIVATED RECEPTOR 1REF NATURE V. 492 387 2012REFN ISSN 0028-0836PMID 23222541DOI 10.1038/NATURE11701 Variant Set Distributions Mapped Variants
General Structure Information 2koe CNR1 human cannabinoid receptor 1 – helix 7/8 peptide -1.0Å AUTH S.TYUKHTENKO,E.K.TIBURU,L.DESHMUKH,O.VINOGRADOVA,AUTH 2 D.R.JANERO,A.MAKRIYANNISTITL NMR SOLUTION STRUCTURE OF HUMAN CANNABINOIDTITL 2 RECEPTOR-1 HELIX 7/8 PEPTIDE: CANDIDATETITL 3 ELECTROSTATIC INTERACTIONS AND MICRODOMAINTITL 4 FORMATION.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 390 441 2009REFN ISSN 0006-291XPMID 19766594DOI 10.1016/J.BBRC.2009.09.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ua5 CYP2B6 crystal structure of p450 2b6 (y226h/k262r) in complex with two molecules of amlodipine 2.8Å AUTH M.B.SHAH,P.R.WILDERMAN,J.PASCUAL,Q.ZHANG,C.D.STOUT,AUTH 2 J.R.HALPERTTITL CONFORMATIONAL ADAPTATION OF HUMAN CYTOCHROME P450 2B6 ANDTITL 2 RABBIT CYTOCHROME P450 2B4 REVEALED UPON BINDING MULTIPLETITL 3 AMLODIPINE MOLECULES.REF BIOCHEMISTRY V. 51 7225 2012REFN ISSN 0006-2960PMID 22909231DOI 10.1021/BI300894Z Variant Set Distributions […]
General Structure Information 2m6i GLRA1 putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit -1.0Å AUTH D.D.MOWREY,T.CUI,Y.JIA,D.MA,A.M.MAKHOV,P.ZHANG,P.TANG,Y.XUTITL OPEN-CHANNEL STRUCTURES OF THE HUMAN GLYCINE RECEPTOR ALPHATITL 2 1 FULL-LENGTH TRANSMEMBRANE DOMAIN.REF STRUCTURE V. 21 1897 2013REFN ISSN 0969-2126PMID 23994010DOI 10.1016/J.STR.2013.07.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3qak ADORA2A agonist bound structure of the human adenosine a2a receptor 2.71Å AUTH F.XU,H.WU,V.KATRITCH,G.W.HAN,K.A.JACOBSON,Z.G.GAO,AUTH 2 V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF AN AGONIST-BOUND HUMAN A2A ADENOSINE RECEPTOR.REF SCIENCE V. 332 322 2011REFN ISSN 0036-8075PMID 21393508DOI 10.1126/SCIENCE.1202793 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants