Assessment of Structural Intolerance and Durability
General Structure Information 3n9v INPP5B crystal structure of inpp5b 2.65Å AUTH L.TRESAUGUES,C.SILVANDER,S.FLODIN,M.WELIN,T.NYMAN,AUTH 2 S.GRASLUND,M.HAMMARSTROM,H.BERGLUND,P.NORDLUNDTITL STRUCTURAL BASIS FOR PHOSPHOINOSITIDE SUBSTRATE RECOGNITION,TITL 2 CATALYSIS, AND MEMBRANE INTERACTIONS IN HUMAN INOSITOLTITL 3 POLYPHOSPHATE 5-PHOSPHATASESREF STRUCTURE V. 22 744 2014REFN ISSN 0969-2126PMID 24704254DOI 10.1016/J.STR.2014.01.013 Variant Set Distributions Mapped Variants
General Structure Information 2v40 ADSS human adenylosuccinate synthetase isozyme 2 in complex with gdp 1.9Å AUTH M.WELIN,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,AUTH 4 L.HOLMBERG-SCHIAVONE,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,T.NYMAN,D.OGG,AUTH 6 C.PERSSON,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 7 A.G.THORSELL,S.VAN-DEN-BERG,J.WEIGELT,P.NORDLUNDTITL HUMAN ADENYLOSUCCINATE SYNTHETASE ISOZYME 2 INTITL 2 COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rop ATP7B solution structure of domains 3 and 4 of human atp7b -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,A.C.ROSENZWEIG,AUTH 2 L.A.YATSUNYKTITL METAL BINDING DOMAINS 3 AND 4 OF THE WILSONTITL 2 DISEASE PROTEIN: SOLUTION STRUCTURE ANDTITL 3 INTERACTION WITH THE COPPER(I) CHAPERONE HAH1REF BIOCHEMISTRY V. 47 7423 2008REFN ISSN 0006-2960PMID 18558714DOI 10.1021/BI8004736 Variant Set Distributions Mapped […]
General Structure Information 3fxm PPM1A crystal structure of human protein phosphatase 1a (ppm1a) bound with citrate at 10 mm of mn2+ 2.5Å AUTH T.HU,L.WANG,K.WANG,J.CHEN,H.JIANG,X.SHENTITL STRUCTURAL BASIS FOR THE MN2+-DEPENDENT ACTIVATIONTITL 2 OF HUMAN PPM1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2koy ATP7B structure of the e1064a mutant of the n-domain of wilson disease associated protein -1.0Å AUTH O.Y.DMITRIEV,S.L.LUTSENKO,E.E.UHLEMANNTITL THE STRUCTURE OF THE E1064A MUTANT REVEALS ATP-DEPENDENTTITL 2 CONFORMATIONAL CHANGES IN THE ATP7B N-DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bi6 WEE1 wee1 kinase complex with inhibitor pd352396 2.2Å AUTH J.B.SMAILL,H.H.LEE,B.D.PALMER,A.M.THOMPSON,AUTH 2 C.J.SQUIRE,E.N.BAKER,R.J.BOOTH,A.KRAKER,K.HOOK,AUTH 3 W.A.DENNYTITL SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OFTITL 2 SOLUBLE 8-SUBSTITUTEDTITL 3 4-(2-CHLOROPHENYL)-9-HYDROXYPYRROLO[3,4-TITL 4 C]CARBAZOLE-1,3(2H,6H)-DIONES AS INHIBITORS OF THETITL 5 WEE1 AND CHK1 CHECKPOINT KINASES.REF BIOORG.MED.CHEM.LETT. V. 18 929 2008REFN ISSN 0960-894XPMID 18191399DOI 10.1016/J.BMCL.2007.12.046 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3bbb NME2 crystal structure of the nm23-h2 transcription factor complex with dinucleotide d(ag) 1.3Å AUTH T.S.DEXHEIMER,S.S.CAREY,S.ZUOHE,V.M.GOKHALE,X.HU,L.B.MURATA,AUTH 2 E.M.MAES,A.WEICHSEL,D.SUN,E.J.MEUILLET,W.R.MONTFORT,AUTH 3 L.H.HURLEYTITL NM23-H2 MAY PLAY AN INDIRECT ROLE IN TRANSCRIPTIONALTITL 2 ACTIVATION OF C-MYC GENE EXPRESSION BUT DOES NOT CLEAVE THETITL 3 NUCLEASE HYPERSENSITIVE ELEMENT III1.REF MOL.CANCER THER. V. 8 1363 2009REFN ISSN 1535-7163PMID […]
General Structure Information 2k8o ITGAL solution structure of integrin alpha l -1.0Å AUTH A.BHUNIA,X.-Y.TANG,H.MOHANRAM,S.-M.TAN,AUTH 2 S.BHATTACHARJYATITL NMR SOLUTION CONFORMATIONS AND INTERACTIONS OFTITL 2 INTEGRIN {ALPHA}L{BETA}2 CYTOPLASMIC TAILSREF J.BIOL.CHEM. V. 284 3873 2009REFN ISSN 0021-9258PMID 19073598DOI 10.1074/JBC.M807236200 Variant Set Distributions Mapped Variants
General Structure Information 3b97 ENO1 crystal structure of human enolase 1 2.2Å AUTH H.J.KANG,S.K.JUNG,S.J.KIM,S.J.CHUNGTITL STRUCTURE OF HUMAN ALPHA-ENOLASE (HENO1), ATITL 2 MULTIFUNCTIONAL GLYCOLYTIC ENZYME.REF ACTA CRYSTALLOGR.,SECT.D V. 64 651 2008REFN ISSN 0907-4449PMID 18560153DOI 10.1107/S0907444908008561 Variant Set Distributions Mapped Variants
General Structure Information 2v3s OXSR1 structural insights into the recognition of substrates and activators by the osr1 kinase 1.7Å AUTH F.VILLA,J.GOEBEL,F.H.RAFIQI,M.DEAK,J.THASTRUP,AUTH 2 D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURAL INSIGHTS INTO THE RECOGNITION OFTITL 2 SUBSTRATES AND ACTIVATORS BY THE OSR1 KINASEREF EMBO REP. V. 8 839 2007REFN ISSN 1469-3178PMID 17721439DOI 10.1038/SJ.EMBOR.7401048 Variant Set Distributions Mapped Variants