Assessment of Structural Intolerance and Durability
General Structure Information 2q7m ALOX5AP crystal structure of human flap with mk-591 4.25Å AUTH A.D.FERGUSON,B.M.MCKEEVER,S.XU,D.WISNIEWSKI,AUTH 2 D.K.MILLER,T.T.YAMIN,R.H.SPENCER,L.CHU,AUTH 3 F.UJJAINWALLA,B.R.CUNNINGHAM,J.F.EVANS,J.W.BECKERTITL CRYSTAL STRUCTURE OF INHIBITOR-BOUND HUMANTITL 2 5-LIPOXYGENASE-ACTIVATING PROTEIN.REF SCIENCE V. 317 510 2007REFN ISSN 0036-8075PMID 17600184DOI 10.1126/SCIENCE.1144346 Variant Set Distributions Mapped Variants
General Structure Information 2obd CETP crystal structure of cholesteryl ester transfer protein 2.1Å AUTH X.QIU,A.MISTRY,M.J.AMMIRATI,B.A.CHRUNYK,R.W.CLARK,AUTH 2 Y.CONG,J.S.CULP,D.E.DANLEY,T.B.FREEMAN,AUTH 3 K.F.GEOGHEGAN,M.C.GRIFFOR,S.J.HAWRYLIK,C.M.HAYWARD,AUTH 4 P.HENSLEY,L.R.HOTH,G.A.KARAM,M.E.LIRA,D.B.LLOYD,AUTH 5 K.M.MCGRATH,K.J.STUTZMAN-ENGWALL,A.K.SUBASHI,AUTH 6 T.A.SUBASHI,J.F.THOMPSON,I.K.WANG,H.ZHAO,A.P.SEDDONTITL CRYSTAL STRUCTURE OF CHOLESTERYL ESTER TRANSFERTITL 2 PROTEIN REVEALS A LONG TUNNEL AND FOUR BOUND LIPIDTITL 3 MOLECULES.REF NAT.STRUCT.MOL.BIOL. V. 14 106 2007REFN ISSN 1545-9993PMID 17237796DOI 10.1038/NSMB1197 Variant Set Distributions […]
General Structure Information 1jfn LPA solution structure of human apolipoprotein(a) kringle iv type 6 -1.0Å AUTH B.MADEREGGER,W.BERMEL,A.HRZENJAK,G.M.KOSTNER,AUTH 2 H.STERKTITL SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A)TITL 2 KRINGLE IV TYPE 6.REF BIOCHEMISTRY V. 41 660 2002REFN ISSN 0006-2960PMID 11781107DOI 10.1021/BI011430K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l7b APOE nmr structure of full length apoe3 -1.0Å AUTH J.CHEN,Q.LI,J.WANGTITL TOPOLOGY OF HUMAN APOLIPOPROTEIN E3 UNIQUELY REGULATES ITSTITL 2 DIVERSE BIOLOGICAL FUNCTIONS.REF PROC.NATL.ACAD.SCI.USA V. 108 14813 2011REFN ISSN 0027-8424PMID 21873229DOI 10.1073/PNAS.1106420108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a01 APOA1 crystal structure of lipid-free human apolipoprotein a-i 2.4Å AUTH A.A.AJEES,G.M.ANANTHARAMAIAH,V.K.MISHRA,AUTH 2 M.M.HUSSAIN,K.H.M.MURTHYTITL CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I:TITL 2 INSIGHTS INTO ITS PROTECTIVE EFFECT AGAINSTTITL 3 CARDIOVASCULAR DISEASES.REF PROC.NATL.ACAD.SCI.USA V. 103 2126 2006REFN ISSN 0027-8424PMID 16452169DOI 10.1073/PNAS.0506877103 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1n7d LDLR extracellular domain of the ldl receptor 3.7Å AUTH G.RUDENKO,L.HENRY,K.HENDERSON,K.ICHTCHENKO,M.S.BROWN,AUTH 2 J.L.GOLDSTEIN,J.DEISENHOFERTITL STRUCTURE OF THE LDL RECEPTOR EXTRACELLULAR DOMAIN ATTITL 2 ENDOSOMAL PHREF SCIENCE V. 298 2353 2002REFN ISSN 0036-8075PMID 12459547DOI 10.1126/SCIENCE.1078124 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants