Assessment of Structural Intolerance and Durability
General Structure Information 2lc3 HECTD1 solution nmr structure of a helical bundle domain from human e3 ligase hectd1. northeast structural genomics consortium (nesg) target ht6305a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.ARROWSMITH,AUTH 2 S.DHE-PAGANONTITL NMR SOLUTION STRUCTURE OF A HELICAL BUNDLE FROM THE E3TITL 2 LIGASE HECTD1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1y8r UBA2 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1y8r SAE1 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Mapped Variants
General Structure Information 2m6n FBXO5 3d solution structure of emi1 (early mitotic inhibitor 1) -1.0Å AUTH J.J.FRYE,N.G.BROWN,G.PETZOLD,E.R.WATSON,C.R.GRACE,A.NOURSE,AUTH 2 M.A.JARVIS,R.W.KRIWACKI,J.M.PETERS,H.STARK,B.A.SCHULMANTITL ELECTRON MICROSCOPY STRUCTURE OF HUMAN APC/C(CDH1)-EMI1TITL 2 REVEALS MULTIMODAL MECHANISM OF E3 LIGASE SHUTDOWN.REF NAT.STRUCT.MOL.BIOL. V. 20 827 2013REFN ISSN 1545-9993PMID 23708605DOI 10.1038/NSMB.2593 Variant Set Distributions Mapped Variants
General Structure Information 3ceg BIRC6 crystal structure of the ubc domain of baculoviral iap repeat- containing protein 6 2.01Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ega PELI2 crystal structure of pellino2 fha domain at 1.8 angstroms resolution 1.8Å AUTH C.C.LIN,Y.S.HUOH,K.R.SCHMITZ,L.E.JENSEN,K.M.FERGUSONTITL PELLINO PROTEINS CONTAIN A CRYPTIC FHA DOMAIN THAT MEDIATESTITL 2 INTERACTION WITH PHOSPHORYLATED IRAK1.REF STRUCTURE V. 16 1806 2008REFN ISSN 0969-2126PMID 19081057DOI 10.1016/J.STR.2008.09.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2jqz SMURF2 solution structure of the c2 domain of human smurf2 -1.0Å AUTH S.WIESNER,A.A.OGUNJIMI,H.-R.WANG,D.ROTIN,F.SICHERI,AUTH 2 J.L.WRANA,J.D.FORMAN-KAYTITL AUTOINHIBITION OF THE HECT-TYPE UBIQUITIN LIGASETITL 2 SMURF2 THROUGH ITS C2 DOMAINREF CELL(CAMBRIDGE,MASS.) V. 130 651 2007REFN ISSN 0092-8674PMID 17719543DOI 10.1016/J.CELL.2007.06.050 Variant Set Distributions Mapped Variants
General Structure Information 4ccg FANCL structure of an e2-e3 complex 2.4Å AUTH C.HODSON,A.PURKISS,J.A.MILES,H.WALDENTITL STRUCTURE OF THE HUMAN FANCL RING-UBE2T COMPLEX REVEALSTITL 2 DETERMINANTS OF COGNATE E3-E2 SELECTION.REF STRUCTURE V. 22 337 2014REFN ISSN 0969-2126PMID 24389026DOI 10.1016/J.STR.2013.12.004 Variant Set Distributions Mapped Variants
General Structure Information 4ccg UBE2T structure of an e2-e3 complex 2.4Å AUTH C.HODSON,A.PURKISS,J.A.MILES,H.WALDENTITL STRUCTURE OF THE HUMAN FANCL RING-UBE2T COMPLEX REVEALSTITL 2 DETERMINANTS OF COGNATE E3-E2 SELECTION.REF STRUCTURE V. 22 337 2014REFN ISSN 0969-2126PMID 24389026DOI 10.1016/J.STR.2013.12.004 Variant Set Distributions Mapped Variants
General Structure Information 1p9o PPCS crystal structure of phosphopantothenoylcysteine synthetase 2.3Å AUTH N.MANOJ,E.STRAUSS,T.P.BEGLEY,S.E.EALICKTITL STRUCTURE OF HUMAN PHOSPHOPANTOTHENOYLCYSTEINETITL 2 SYNTHETASE AT 2.3 A RESOLUTION.REF STRUCTURE V. 11 927 2003REFN ISSN 0969-2126PMID 12906824DOI 10.1016/S0969-2126(03)00146-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants