Assessment of Structural Intolerance and Durability
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hlq BMPR2 crystal structure of the extracellular domain of the type ii bmp receptor 1.45Å AUTH P.D.MACE,J.F.CUTFIELD,S.M.CUTFIELDTITL HIGH RESOLUTION STRUCTURES OF THE BONETITL 2 MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN TWOTITL 3 CRYSTAL FORMS: IMPLICATIONS FOR LIGAND BINDINGREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 351 831 2006REFN ISSN 0006-291XPMID 17094948DOI 10.1016/J.BBRC.2006.10.109 Variant Set Distributions Mapped Variants
General Structure Information 1j8e LRP1 crystal structure of ligand-binding repeat cr7 from lrp 1.85Å AUTH M.SIMONOVIC,K.DOLMER,W.HUANG,D.K.STRICKLAND,K.VOLZ,AUTH 2 P.G.GETTINSTITL CALCIUM COORDINATION AND PH DEPENDENCE OF THETITL 2 CALCIUM AFFINITY OF LIGAND-BINDING REPEAT CR7 FROMTITL 3 THE LRP. COMPARISON WITH RELATED DOMAINS FROM THETITL 4 LRP AND THE LDL RECEPTOR.REF BIOCHEMISTRY V. 40 15127 2001REFN ISSN 0006-2960PMID […]
General Structure Information 2knx LRP1 solution structure of complement repeat cr17 from lrp-1 -1.0Å AUTH M.GUTTMAN,J.H.PRIETO,T.M.HANDEL,P.J.DOMAILLE,E.A.KOMIVESTITL STRUCTURE OF THE MINIMAL INTERFACE BETWEEN APOE AND LRP.REF J.MOL.BIOL. V. 398 306 2010REFN ISSN 0022-2836PMID 20303980DOI 10.1016/J.JMB.2010.03.022 Variant Set Distributions Mapped Variants
General Structure Information 2h2b TJP1 crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttyl) 1.6Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,N.J.SKELTON,AUTH 2 S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZ DOMAIN ANDTITL 2 THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTS INTO DETERMINANTS OFTITL 3 PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant […]
General Structure Information 2p3w HTRA3 crystal structure of the htra3 pdz domain bound to a phage-derived ligand (fgrwv) 1.7Å AUTH S.T.RUNYON,Y.ZHANG,B.A.APPLETON,S.L.SAZINSKY,P.WU,B.PAN,AUTH 2 C.WIESMANN,N.J.SKELTON,S.S.SIDHUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PDZ DOMAINS OFTITL 2 HUMAN HTRA1 AND HTRA3.REF PROTEIN SCI. V. 16 2454 2007REFN ISSN 0961-8368PMID 17962403DOI 10.1110/PS.073049407 Variant Set Distributions Mapped Variants
General Structure Information 2p3w HTRA3 crystal structure of the htra3 pdz domain bound to a phage-derived ligand (fgrwv) 1.7Å AUTH S.T.RUNYON,Y.ZHANG,B.A.APPLETON,S.L.SAZINSKY,P.WU,B.PAN,AUTH 2 C.WIESMANN,N.J.SKELTON,S.S.SIDHUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PDZ DOMAINS OFTITL 2 HUMAN HTRA1 AND HTRA3.REF PROTEIN SCI. V. 16 2454 2007REFN ISSN 0961-8368PMID 17962403DOI 10.1110/PS.073049407 Variant Set Distributions Mapped Variants
General Structure Information 1j8e LRP1 crystal structure of ligand-binding repeat cr7 from lrp 1.85Å AUTH M.SIMONOVIC,K.DOLMER,W.HUANG,D.K.STRICKLAND,K.VOLZ,AUTH 2 P.G.GETTINSTITL CALCIUM COORDINATION AND PH DEPENDENCE OF THETITL 2 CALCIUM AFFINITY OF LIGAND-BINDING REPEAT CR7 FROMTITL 3 THE LRP. COMPARISON WITH RELATED DOMAINS FROM THETITL 4 LRP AND THE LDL RECEPTOR.REF BIOCHEMISTRY V. 40 15127 2001REFN ISSN 0006-2960PMID […]
General Structure Information 2knx LRP1 solution structure of complement repeat cr17 from lrp-1 -1.0Å AUTH M.GUTTMAN,J.H.PRIETO,T.M.HANDEL,P.J.DOMAILLE,E.A.KOMIVESTITL STRUCTURE OF THE MINIMAL INTERFACE BETWEEN APOE AND LRP.REF J.MOL.BIOL. V. 398 306 2010REFN ISSN 0022-2836PMID 20303980DOI 10.1016/J.JMB.2010.03.022 Variant Set Distributions Mapped Variants
General Structure Information 2h2b TJP1 crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttyl) 1.6Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,N.J.SKELTON,AUTH 2 S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZ DOMAIN ANDTITL 2 THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTS INTO DETERMINANTS OFTITL 3 PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant […]