Assessment of Structural Intolerance and Durability
General Structure Information 4g8a LY96 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3w3g TLR8 crystal structure of human tlr8 (unliganded form) 2.3Å AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b2d CD180 crystal structure of human rp105/md-1 complex 2.8Å AUTH U.OHTO,K.MIYAKE,T.SHIMIZUTITL CRYSTAL STRUCTURES OF MOUSE AND HUMAN RP105/MD-1 COMPLEXESTITL 2 REVEAL UNIQUE DIMER ORGANIZATION OF THE TOLL-LIKE RECEPTORTITL 3 FAMILY.REF J.MOL.BIOL. V. 413 815 2011REFN ISSN 0022-2836PMID 21959264DOI 10.1016/J.JMB.2011.09.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3un9 NLRX1 crystal structure of an immune receptor 2.65Å AUTH M.HONG,S.I.YOON,I.A.WILSONTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE RNA-BINDINGTITL 2 ELEMENT OF THE NLRX1 INNATE IMMUNE MODULATOR.REF IMMUNITY V. 36 337 2012REFN ISSN 1074-7613PMID 22386589DOI 10.1016/J.IMMUNI.2011.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ecc HOMEZ solution structure of the second homeobox domain of human homeodomain leucine zipper-encoding gene (homez) -1.0Å AUTH S.OHNISHI,Y.O.KAMATARI,N.TOCHIO,N.KOBAYASHI,AUTH 2 S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND HOMEOBOX DOMAINTITL 2 OF HUMAN HOMEODOMAIN LEUCINE ZIPPER-ENCODING GENETITL 3 (HOMEZ)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants