Assessment of Structural Intolerance and Durability
General Structure Information 3cw3 AIM1 crystal structure of aim1g1 1.88Å AUTH P.ARAVIND,G.WISTOW,Y.SHARMA,R.SANKARANARAYANANTITL EXPLORING THE LIMITS OF SEQUENCE AND STRUCTURE IN A VARIANTTITL 2 BETAGAMMA-CRYSTALLIN DOMAIN OF THE PROTEIN ABSENT INTITL 3 MELANOMA-1 (AIM1).REF J.MOL.BIOL. V. 381 509 2008REFN ISSN 0022-2836PMID 18582473DOI 10.1016/J.JMB.2008.06.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3kqg CD207 trimeric structure of langerin 2.3Å AUTH H.FEINBERG,A.S.POWLESLAND,M.E.TAYLOR,W.I.WEISTITL TRIMERIC STRUCTURE OF LANGERIN.REF J.BIOL.CHEM. V. 285 13285 2010REFN ISSN 0021-9258PMID 20181944DOI 10.1074/JBC.M109.086058 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c6u CLEC1B crystal structure of human clec-2 (clec1b) 1.6Å AUTH A.A.WATSON,J.BROWN,K.HARLOS,J.A.EBLE,T.S.WALTER,AUTH 2 C.A.OCALLAGHANTITL THE CRYSTAL STRUCTURE AND MUTATIONAL BINDINGTITL 2 ANALYSIS OF THE EXTRACELLULAR DOMAIN OF THETITL 3 PLATELET-ACTIVATING RECEPTOR CLEC-2.REF J.BIOL.CHEM. V. 282 3165 2007REFN ISSN 0021-9258PMID 17132623DOI 10.1074/JBC.M610383200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3wh2 CLEC4E human mincle in complex with citrate 1.3Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1k9i CD209 complex of dc-sign and glcnac2man3 2.5Å AUTH H.FEINBERG,D.A.MITCHELL,K.DRICKAMER,W.I.WEISTITL STRUCTURAL BASIS FOR SELECTIVE RECOGNITION OFTITL 2 OLIGOSACCHARIDES BY DC-SIGN AND DC-SIGNR.REF SCIENCE V. 294 2163 2001REFN ISSN 0036-8075PMID 11739956DOI 10.1126/SCIENCE.1066371 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1sl6 CLEC4M crystal structure of a fragment of dc-signr (containg the carbohydrate recognition domain and two repeats of the neck) complexed with lewis-x. 2.25Å AUTH Y.GUO,H.FEINBERG,E.CONROY,D.A.MITCHELL,R.ALVAREZ,AUTH 2 O.BLIXT,M.E.TAYLOR,W.I.WEIS,K.DRICKAMERTITL STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING ANDTITL 2 TARGETING PROPERTIES OF THE RECEPTORS DC-SIGN ANDTITL 3 DC-SIGNRREF NAT.STRUCT.MOL.BIOL. V. 11 591 2004REFN ISSN 1545-9993PMID 15195147DOI […]
General Structure Information 2kv3 REG4 human regenerating gene type iv (reg iv) protein, p91s mutant -1.0Å AUTH M.HO,Y.LOU,S.WEI,S.LUO,W.LIN,P.LYU,C.CHENTITL HUMAN REGIV PROTEIN ADOPTS A TYPICAL C-TYPE LECTIN FOLD BUTTITL 2 BINDS MANNAN WITH TWO CALCIUM-INDEPENDENT SITESREF J.MOL.BIOL. 2010REFN ESSN 1089-8638DOI 10.1016/J.JMB.2010.07.061 Variant Set Distributions Mapped Variants
General Structure Information 3whd CLEC4D c-type lectin, human mcl 2.29Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 3wbp CLEC4C crystal structure of carbohydrate recognition domain of blood dendritic cell antigen-2 (bdca2) lectin (crystal form-1) 1.8Å AUTH M.NAGAE,A.IKEDA,Y.KITAGO,N.MATSUMOTO,K.YAMAMOTO,Y.YAMAGUCHITITL CRYSTAL STRUCTURES OF CARBOHYDRATE RECOGNITION DOMAIN OFTITL 2 BLOOD DENDRITIC CELL ANTIGEN-2 (BDCA2) REVEAL A COMMONTITL 3 DOMAIN-SWAPPED DIMERREF PROTEINS 2013REFN ESSN 1097-0134PMID 24425442DOI 10.1002/PROT.24504 Variant Set Distributions Ripley’s K Analysis Plots […]