3TXO.A | PRKCH

General Structure Information 3txo PRKCH pkc eta kinase in complex with a naphthyridine 2.05Å AUTH M.J.VAN EIS,J.P.EVENOU,P.FLOERSHEIM,C.GAUL,S.W.COWAN-JACOB,AUTH 2 L.MONOVICH,G.RUMMEL,W.SCHULER,W.STARK,A.STRAUSS,A.MATT,AUTH 3 E.VANGREVELINGHE,J.WAGNER,N.SOLDERMANNTITL 2,6-NAPHTHYRIDINES AS POTENT AND SELECTIVE INHIBITORS OF THETITL 2 NOVEL PROTEIN KINASE C ISOZYMES.REF BIOORG.MED.CHEM.LETT. V. 21 7367 2011REFN ISSN 0960-894XPMID 22078216DOI 10.1016/J.BMCL.2011.10.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]

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3OP3.A | CDC25C

General Structure Information 3op3 CDC25C crystal structure of cell division cycle 25c protein isoform a from homo sapiens 2.63Å AUTH Y.KIM,A.WEGER,C.HATZOS,P.SAVITSKY,C.JOHANSSON,L.BALL,A.BARR,AUTH 2 M.VOLLMAR,J.MUNIZ,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,O.GILEADI,F.VON DELFT,S.KNAPP,A.JOACHIMIAKTITL CRYSTAL STRUCTURE OF CELL DIVISION CYCLE 25C PROTEIN ISOFORMTITL 2 A FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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3IPY.A | DCK

General Structure Information 3ipy DCK x-ray structure of human deoxycytidine kinase in complex with an inhibitor 2.54Å AUTH T.C.JESSOP,J.E.TARVER,M.CARLSEN,A.XU,J.P.HEALY,AUTH 2 A.HEIM-RIETHER,Q.FU,J.A.TAYLOR,D.J.AUGERI,M.SHEN,T.R.STOUCH,AUTH 3 R.V.SWANSON,L.W.TARI,M.HUNTER,I.HOFFMAN,P.E.KEYES,X.C.YU,AUTH 4 M.MIRANDA,Q.LIU,J.C.SWAFFIELD,S.DAVID KIMBALL,A.NOURALDEEN,AUTH 5 A.G.WILSON,A.M.FOUSHEE,K.JHAVER,R.FINCH,S.ANDERSON,AUTH 6 T.ORAVECZ,K.G.CARSONTITL LEAD OPTIMIZATION AND STRUCTURE-BASED DESIGN OF POTENT ANDTITL 2 BIOAVAILABLE DEOXYCYTIDINE KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6784 2009REFN ISSN 0960-894XPMID 19836232DOI 10.1016/J.BMCL.2009.09.081 Variant Set Distributions […]

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2W99.A | CCND1

General Structure Information 2w99 CCND1 crystal structure of cdk4 in complex with a d-type cyclin 2.8Å AUTH P.J.DAY,A.CLEASBY,I.J.TICKLE,M.OREILLY,J.E.COYLE,AUTH 2 F.P.HOLDING,R.L.MCMENAMIN,J.YON,R.CHOPRA,AUTH 3 C.LENGAUER,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CDK4 IN COMPLEX WITH ATITL 2 D-TYPE CYCLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 4166 2009REFN ISSN 0027-8424PMID 19237565DOI 10.1073/PNAS.0809645106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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3KUL.B | EPHA8

General Structure Information 3kul EPHA8 kinase domain of human ephrin type-a receptor 8 (epha8) 2.15Å AUTH J.R.WALKER,L.YERMEKBAYEVA,J.KANIA,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 8 (EPHA8)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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1TUZ.A | DGKA

General Structure Information 1tuz DGKA nmr structure of the diacylglycerol kinase alpha, nesgc target hr532 -1.0Å AUTH G.LIU,Y.SHAO,R.XIAO,T.ACTON,G.T.MONTELIONE,AUTH 2 T.SZYPERSKITITL NMR STRUCTURE OF DIACYLGLYCEROL KINASE ALPHA,TITL 2 NESGC TARGET HR532REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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3G33.D | CCND3

General Structure Information 3g33 CCND3 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Mapped Variants

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3DRE.A | CKB

General Structure Information 3dre CKB crystal structure of human brain-type creatine kinase 2.2Å AUTH S.M.BONG,J.H.MOON,K.H.NAM,K.S.LEE,Y.M.CHI,K.Y.HWANGTITL STRUCTURAL STUDIES OF HUMAN BRAIN-TYPE CREATINETITL 2 KINASE COMPLEXED WITH THE ADP-MG2+-NO3- -CREATINETITL 3 TRANSITION-STATE ANALOGUE COMPLEXREF FEBS LETT. V. 582 3959 2008REFN ISSN 0014-5793PMID 18977227DOI 10.1016/J.FEBSLET.2008.10.039 Variant Set Distributions Mapped Variants

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3II5.A | BRAF

General Structure Information 3ii5 BRAF the complex of wild-type b-raf with pyrazolo pyrimidine inhibitor 2.79Å AUTH D.M.BERGER,N.TORRES,M.DUTIA,D.POWELL,G.CISZEWSKI,AUTH 2 A.GOPALSAMY,J.I.LEVIN,K.H.KIM,W.XU,J.WILHELM,Y.HU,AUTH 3 K.COLLINS,L.FELDBERG,S.KIM,E.FROMMER,AUTH 4 D.WOJCIECHOWICZ,R.MALLONTITL NON-HINGE-BINDING PYRAZOLO[1,5-A]PYRIMIDINES ASTITL 2 POTENT B-RAF KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6519 2009REFN ISSN 0960-894XPMID 19864136DOI 10.1016/J.BMCL.2009.10.049 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3IW4.C | PRKCA

General Structure Information 3iw4 PRKCA crystal structure of pkc alpha in complex with nvp-aeb071 2.8Å AUTH J.WAGNER,P.VON MATT,R.SEDRANI,R.ALBERT,N.COOKE,C.EHRHARDT,AUTH 2 M.GEISER,G.RUMMEL,W.STARK,A.STRAUSS,S.W.COWAN-JACOB,AUTH 3 C.BEERLI,G.WECKBECKER,J.P.EVENOU,G.ZENKE,S.COTTENSTITL DISCOVERY OFTITL 2 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-TITL 3 YL]PYRROLE-2,5-DIONE (AEB071), A POTENT AND SELECTIVETITL 4 INHIBITOR OF PROTEIN KINASE C ISOTYPESREF J.MED.CHEM. V. 52 6193 2009REFN ISSN 0022-2623PMID 19827831DOI 10.1021/JM901108B Variant Set Distributions Ripley’s K Analysis […]

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