Assessment of Structural Intolerance and Durability
General Structure Information 1xwn PPIL1 solution structure of cyclophilin like 1(ppil1) and insights into its interaction with skip -1.0Å AUTH C.XU,J.ZHANG,X.HUANG,J.SUN,Y.XU,Y.TANG,J.WU,Y.SHI,AUTH 2 Q.HUANG,Q.ZHANGTITL SOLUTION STRUCTURE OF HUMAN PEPTIDYL PROLYLTITL 2 ISOMERASE LIKE PROTEIN 1 AND INSIGHTS INTO ITSTITL 3 INTERACTION WITH SKIPREF J.BIOL.CHEM. V. 281 15900 2006REFN ISSN 0021-9258PMID 16595688DOI 10.1074/JBC.M511155200 Variant Set Distributions Mapped […]
General Structure Information 2r99 PPIE crystal structure of cyclophilin abh-like domain of human peptidylprolyl isomerase e isoform 1 1.61Å AUTH J.R.WALKER,T.DAVIS,E.M.NEWMAN,F.MACKENZIE,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL X-RAY CRYSTAL STRUCTURE OF THE CYCLOPHILIN DOMAINTITL 2 OF HUMAN PEPTIDYLPROLYL ISOMERASE E ISOFORM 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kyx PPIE solution structure of the rrm domain of cyp33 -1.0Å AUTH S.PARK,U.OSMERS,G.RAMAN,R.H.SCHWANTES,M.O.DIAZ,AUTH 2 J.H.BUSHWELLERTITL THE PHD3 DOMAIN OF MLL ACTS AS A CYP33-REGULATED SWITCHTITL 2 BETWEEN MLL-MEDIATED ACTIVATION AND REPRESSION .REF BIOCHEMISTRY V. 49 6576 2010REFN ISSN 0006-2960PMID 20677832DOI 10.1021/BI1009387 Variant Set Distributions Mapped Variants
General Structure Information 3zi1 GLOD4 crystal structure of human glyoxalase domain-containing protein 4 (glod4) 1.9Å AUTH A.OBERHOLZE,W.KIYANI,L.SHRESTHA,M.VOLLMAR,T.KROJER,AUTH 2 D.S.FROESE,E.WILLIAMS,F.VON DELFT,N.BURGESS-BROWN,AUTH 3 C.H.ARROWSMITH,A.EDWARDS,C.BOUNTRA,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN GLYOXALASE DOMAIN- CONTAININGTITL 2 PROTEIN 4 (GLOD4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4msp FKBP14 crystal structure of human peptidyl-prolyl cis-trans isomerase fkbp22 (aka fkbp14) containing two ef-hand motifs 1.9Å AUTH S.P.BOUDKO,Y.ISHIKAWA,J.NIX,M.S.CHAPMAN,H.P.BACHINGERTITL STRUCTURE OF HUMAN PEPTIDYL-PROLYL CIS-TRANS ISOMERASETITL 2 FKBP22 CONTAINING TWO EF-HAND MOTIFS.REF PROTEIN SCI. V. 23 67 2014REFN ISSN 0961-8368PMID 24272907DOI 10.1002/PRO.2391 Variant Set Distributions Mapped Variants
General Structure Information 4b4o SDR39U1 crystal structure of human epimerase family protein sdr39u1 (isoform2) with nadph 2.7Å AUTH M.VOLLMAR,J.R.C.MUNIZ,N.SHAFQAT,S.PICAUD,T.KROJER,AUTH 2 A.CHAIKUAD,A.C.W.PIKE,W.W.YUE,P.FILIPPAKOPOULOS,AUTH 3 K.L.KAVANAGH,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,C.BOUNTRA,AUTH 4 A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN EPIMERASE FAMILY PROTEIN SDR39U1TITL 2 (ISOFORM2) WITH NADPHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3dcy C12orf5 crystal structure a tp53-induced glycolysis and apoptosis regulator protein from homo sapiens. 1.75Å AUTH J.G.MCCOY,C.A.BINGMAN,G.E.WESENBERG,AUTH 2 G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE A TP53-INDUCED GLYCOLYSIS ANDTITL 2 APOPTOSIS REGULATOR PROTEIN FROM HOMO SAPIENS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l6b SRR x-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor 1.5Å AUTH M.A.SMITH,V.MACK,A.EBNETH,I.MORAES,B.FELICETTI,M.WOOD,AUTH 2 D.SCHONFELD,O.MATHER,A.CESURA,J.BARKERTITL THE STRUCTURE OF MAMMALIAN SERINE RACEMASE: EVIDENCE FORTITL 2 CONFORMATIONAL CHANGES UPON INHIBITOR BINDING.REF J.BIOL.CHEM. V. 285 12873 2010REFN ISSN 0021-9258PMID 20106978DOI 10.1074/JBC.M109.050062 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2pny IDI2 structure of human isopentenyl-diphosphate delta-isomerase 2 1.81Å AUTH J.R.WALKER,T.DAVIS,C.BUTLER-COLE,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE HUMAN ISOPENTENYL-DIPHOSPHATETITL 2 DELTA-ISOMERASE 2.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3rmu MCEE crystal structure of human methylmalonyl-coa epimerase, mcee 1.8Å AUTH A.CHAIKUAD,E.KRYSZTOFINSKA,D.S.FROESE,W.W.YUE,M.VOLLMAR,AUTH 2 J.R.C.MUNIZ,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA EPIMERASE, MCEEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants