Assessment of Structural Intolerance and Durability
General Structure Information 2m1x TICAM1 ticam-1 tir domain structure -1.0Å AUTH Y.ENOKIZONO,H.KUMETA,K.FUNAMI,M.HORIUCHI,J.SARMIENTO,AUTH 2 K.YAMASHITA,D.M.STANDLEY,M.MATSUMOTO,T.SEYA,F.INAGAKITITL STRUCTURES AND INTERFACE MAPPING OF THE TIRTITL 2 DOMAIN-CONTAINING ADAPTOR MOLECULES INVOLVED IN INTERFERONTITL 3 SIGNALING.REF PROC.NATL.ACAD.SCI.USA V. 110 19908 2013REFN ISSN 0027-8424PMID 24255114DOI 10.1073/PNAS.1222811110 Variant Set Distributions Mapped Variants
General Structure Information 3hhc IFNL3 interferon-lambda is functionally an interferon but structurally related to the il-10 family 2.8Å AUTH H.H.GAD,C.DELLGREN,O.J.HAMMING,S.VENDS,S.R.PALUDAN,AUTH 2 R.HARTMANNTITL INTERFERON-{LAMBDA} IS FUNCTIONALLY AN INTERFERONTITL 2 BUT STRUCTURALLY RELATED TO THE INTERLEUKIN-10TITL 3 FAMILYREF J.BIOL.CHEM. V. 284 20869 2009REFN ISSN 0021-9258PMID 19457860DOI 10.1074/JBC.M109.002923 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2m1w TICAM2 ticam-2 tir domain -1.0Å AUTH Y.ENOKIZONO,H.KUMETA,K.FUNAMI,M.HORIUCHI,J.SARMIENTO,AUTH 2 K.YAMASHITA,D.M.STANDLEY,M.MATSUMOTO,T.SEYA,F.INAGAKITITL STRUCTURES AND INTERFACE MAPPING OF THE TIRTITL 2 DOMAIN-CONTAINING ADAPTOR MOLECULES INVOLVED IN INTERFERONTITL 3 SIGNALING.REF PROC.NATL.ACAD.SCI.USA V. 110 19908 2013REFN ISSN 0027-8424PMID 24255114DOI 10.1073/PNAS.1222811110 Variant Set Distributions Mapped Variants
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dll IRF4 solution structure of the irf domain of human interferon regulator factors 4 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IRF DOMAIN OF HUMANTITL 2 INTERFERON REGULATOR FACTORS 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants
General Structure Information 1xmk ADAR the crystal structure of the zb domain from the rna editing enzyme adar1 0.97Å AUTH A.ATHANASIADIS,D.PLACIDO,S.MAAS,B.A.BROWN II,AUTH 2 K.LOWENHAUPT,A.RICHTITL THE CRYSTAL STRUCTURE OF THE Z[BETA] DOMAIN OF THETITL 2 RNA-EDITING ENZYME ADAR1 REVEALS DISTINCTTITL 3 CONSERVED SURFACES AMONG Z-DOMAINS.REF J.MOL.BIOL. V. 351 496 2005REFN ISSN 0022-2836PMID 16023667DOI 10.1016/J.JMB.2005.06.028 Variant Set […]
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants