Assessment of Structural Intolerance and Durability
General Structure Information 2vjf MDM2 crystal structure of the mdm2-mdmx ring domain heterodimer 2.3Å AUTH K.LINKE,P.D.MACE,C.A.SMITH,D.L.VAUX,J.SILKE,C.L.DAYTITL STRUCTURE OF THE MDM2/MDMX RING DOMAIN HETERODIMERTITL 2 REVEALS DIMERIZATION IS REQUIRED FOR THEIRTITL 3 UBIQUITYLATION IN TRANS.REF CELL DEATH DIFFER. V. 15 841 2008REFN ISSN 1350-9047PMID 18219319DOI 10.1038/SJ.CDD.4402309 Variant Set Distributions Mapped Variants
General Structure Information 3c7x MMP14 hemopexin-like domain of matrix metalloproteinase 14 1.7Å AUTH A.TOCHOWICZ,P.GOETTIG,R.EVANS,R.VISSE,Y.SHITOMI,R.PALMISANO,AUTH 2 N.ITO,K.RICHTER,K.MASKOS,D.FRANKE,D.SVERGUN,H.NAGASE,W.BODE,AUTH 3 Y.ITOHTITL THE DIMER INTERFACE OF THE MEMBRANE TYPE 1 MATRIXTITL 2 METALLOPROTEINASE HEMOPEXIN DOMAIN: CRYSTAL STRUCTURE ANDTITL 3 BIOLOGICAL FUNCTIONSREF J.BIOL.CHEM. V. 286 7587 2011REFN ISSN 0021-9258PMID 21193411DOI 10.1074/JBC.M110.178434 Variant Set Distributions Mapped Variants
General Structure Information 1z29 SULT1A2 crystal structures of sult1a2 and sult1a1*3: implications in the bioactivation of n-hydroxy-2-acetylamino fluorine (oh-aaf) 2.4Å AUTH J.LU,H.LI,J.ZHANG,M.LI,M.Y.LIU,X.AN,M.C.LIU,W.CHANGTITL CRYSTAL STRUCTURES OF SULT1A2 AND SULT1A1 *3: INSIGHTS INTOTITL 2 THE SUBSTRATE INHIBITION AND THE ROLE OF TYR149 IN SULT1A2.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 396 429 2010REFN ISSN 0006-291XPMID 20417180DOI 10.1016/J.BBRC.2010.04.109 Variant Set Distributions Ripley’s […]
General Structure Information 2hle EFNB2 structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity. 2.05Å AUTH J.E.CHRENCIK,A.BROOUN,M.L.KRAUS,M.I.RECHT,A.R.KOLATKAR,AUTH 2 G.W.HAN,J.M.SEIFERT,H.WIDMER,M.AUER,P.KUHNTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THETITL 2 EPHB4-EPHRINB2 PROTEIN-PROTEIN INTERACTION AND RECEPTORTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 281 28185 2006REFN ISSN 0021-9258PMID 16867992DOI 10.1074/JBC.M605766200 Variant Set Distributions Mapped Variants
General Structure Information 2le3 CPT1A n-terminal regulatory segment of carnitine palmitoyltransferase 1a -1.0Å AUTH J.N.RAO,G.Z.WARREN,S.ESTOLT-POVEDANO,V.A.ZAMMIT,T.S.ULMERTITL AN ENVIRONMENT-DEPENDENT STRUCTURAL SWITCH UNDERLIES THETITL 2 REGULATION OF CARNITINE PALMITOYLTRANSFERASE 1A.REF J.BIOL.CHEM. V. 286 42545 2011REFN ISSN 0021-9258PMID 21990363DOI 10.1074/JBC.M111.306951 Variant Set Distributions Mapped Variants
General Structure Information 2ka4 STAT2 nmr structure of the cbp-taz1/stat2-tad complex -1.0Å AUTH J.M.WOJCIAK,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR RECRUITMENT OF CBP/P300TITL 2 COACTIVATORS BY STAT1 AND STAT2 TRANSACTIVATIONTITL 3 DOMAINSREF EMBO J. V. 28 948 2009REFN ISSN 0261-4189PMID 19214187DOI 10.1038/EMBOJ.2009.30 Variant Set Distributions Mapped Variants
General Structure Information 3mx0 EFNA5 crystal structure of epha2 ectodomain in complex with ephrin-a5 3.51Å AUTH J.P.HIMANEN,L.YERMEKBAYEVA,P.W.JANES,J.R.WALKER,K.XU,AUTH 2 L.ATAPATTU,K.R.RAJASHANKAR,A.MENSINGA,M.LACKMANN,AUTH 3 D.B.NIKOLOV,S.DHE-PAGANONTITL ARCHITECTURE OF EPH RECEPTOR CLUSTERS.REF PROC.NATL.ACAD.SCI.USA V. 107 10860 2010REFN ISSN 0027-8424PMID 20505120DOI 10.1073/PNAS.1004148107 Variant Set Distributions Mapped Variants
General Structure Information 1x0h IQGAP1 solution structure of the carboxyl-terminal rgc domain in human iqgap1 -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CARBOXYL-TERMINAL RGCTITL 2 DOMAIN IN HUMAN IQGAP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fey KPNA2 crystal structure of the cbc-importin alpha complex. 2.2Å AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649 Variant Set Distributions Mapped Variants
General Structure Information 1oqy RAD23A structure of the dna repair protein hhr23a -1.0Å AUTH K.J.WALTERS,P.J.LECH,A.M.GOH,Q.WANG,P.M.HOWLEYTITL DNA-REPAIR PROTEIN HHR23A ALTERS ITS PROTEINTITL 2 STRUCTURE UPON BINDING PROTEASOMAL SUBUNIT S5AREF PROC.NATL.ACAD.SCI.USA V. 100 12694 2003REFN ISSN 0027-8424PMID 14557549DOI 10.1073/PNAS.1634989100 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants