Assessment of Structural Intolerance and Durability
General Structure Information 1yjr ATP7A solution structure of the apo form of the sixth soluble domain a69p mutant of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,A.ROSATO,AUTH 2 S.WANGTITL AN ATOMIC-LEVEL INVESTIGATION OF THETITL 2 DISEASE-CAUSING A629P MUTANT OF THE MENKESTITL 3 PROTEIN, ATP7AREF J.MOL.BIOL. V. 352 409 2005REFN ISSN 0022-2836PMID 16083905DOI 10.1016/J.JMB.2005.07.034 Variant Set Distributions Mapped Variants
General Structure Information 1yjr ATP7A solution structure of the apo form of the sixth soluble domain a69p mutant of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,A.ROSATO,AUTH 2 S.WANGTITL AN ATOMIC-LEVEL INVESTIGATION OF THETITL 2 DISEASE-CAUSING A629P MUTANT OF THE MENKESTITL 3 PROTEIN, ATP7AREF J.MOL.BIOL. V. 352 409 2005REFN ISSN 0022-2836PMID 16083905DOI 10.1016/J.JMB.2005.07.034 Variant Set Distributions Mapped Variants
General Structure Information 3io2 EP300 crystal structure of the taz2 domain of p300 2.5Å AUTH M.MILLER,Z.DAUTER,S.CHERRY,J.E.TROPEA,A.WLODAWERTITL STRUCTURE OF THE TAZ2 DOMAIN OF P300: INSIGHTS INTO LIGANDTITL 2 BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 65 1301 2009REFN ISSN 0907-4449PMID 19966416DOI 10.1107/S0907444909040153 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3vyx DHX9 structural insights into risc assembly facilitated by dsrna binding domains of human rna helicase (dhx9) 2.29Å AUTH Q.FU,Y.A.YUANTITL STRUCTURAL INSIGHTS INTO RISC ASSEMBLY FACILITATED BYTITL 2 DSRNA-BINDING DOMAINS OF HUMAN RNA HELICASE A (DHX9)REF NUCLEIC ACIDS RES. 2013REFN ESSN 1362-4962PMID 23361462DOI 10.1093/NAR/GKT042 Variant Set Distributions Mapped Variants
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k2p TIAM1 the structure of a quintuple mutant of the tiam1 ph-cc-ex domain 1.98Å AUTH M.JOSHI,L.GAKHAR,E.J.FUENTESTITL HIGH-RESOLUTION STRUCTURE OF THE TIAM1 PHN-CC-EX DOMAIN.REF ACTA CRYSTALLOGR.,SECT.F V. 69 744 2013REFN ESSN 1744-3091PMID 23832200DOI 10.1107/S1744309113014206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2bkd FMR1 structure of the n-terminal domain of fragile x mental retardation protein -1.0Å AUTH A.RAMOS,D.HOLLINGWORTH,S.ADINOLFI,M.CASTETS,AUTH 2 G.KELLY,T.A.FRENKIEL,B.BARDONI,A.PASTORETITL THE STRUCTURE OF THE N-TERMINAL DOMAIN OF THETITL 2 FRAGILE X MENTAL RETARDATION PROTEIN: A PLATFORMTITL 3 FOR PROTEIN-PROTEIN INTERACTION.REF STRUCTURE V. 14 21 2006REFN ISSN 0969-2126PMID 16407062DOI 10.1016/J.STR.2005.09.018 Variant Set Distributions Mapped Variants
General Structure Information 4a04 TBX1 structure of the dna-bound t-box domain of human tbx1, a transcription factor associated with the digeorge syndrome 2.58Å AUTH K.EL OMARI,J.DE MESMAEKER,D.KARIA,H.GINN,S.BHATTACHARYA,AUTH 2 E.J.MANCINITITL STRUCTURE OF THE DNA-BOUND T-BOX DOMAIN OF HUMAN TBX1, ATITL 2 TRANSCRIPTION FACTOR ASSOCIATED WITH THE DIGEORGE SYNDROMEREF PROTEINS V. 80 655 2012REFN ISSN 0887-3585PMID 22095455DOI […]
General Structure Information 2odd RUNX1T1 solution structure of the mynd domain from aml1-eto complexed with smrt, a corepressor -1.0Å AUTH Y.LIU,W.CHEN,J.GAUDET,M.D.CHENEY,L.ROUDAIA,AUTH 2 T.CIERPICKI,R.C.KLET,K.HARTMAN,T.M.LAUE,N.A.SPECK,AUTH 3 J.H.BUSHWELLERTITL STRUCTURAL BASIS FOR RECOGNITION OF SMRT/N-COR BYTITL 2 THE MYND DOMAIN AND ITS CONTRIBUTION TO AML1/ETOSTITL 3 ACTIVITY.REF CANCER CELL V. 11 483 2007REFN ISSN 1535-6108PMID 17560331DOI 10.1016/J.CCR.2007.04.010 Variant Set […]
General Structure Information 3crd CRADD nmr structure of the raidd card domain, 15 structures -1.0Å AUTH J.J.CHOU,H.MATSUO,H.DUAN,G.WAGNERTITL SOLUTION STRUCTURE OF THE RAIDD CARD AND MODEL FORTITL 2 CARD/CARD INTERACTION IN CASPASE-2 AND CASPASE-9TITL 3 RECRUITMENT.REF CELL(CAMBRIDGE,MASS.) V. 94 171 1998REFN ISSN 0092-8674PMID 9695946DOI 10.1016/S0092-8674(00)81417-8 Variant Set Distributions Mapped Variants