Assessment of Structural Intolerance and Durability
General Structure Information 2c01 RNASE2 crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5-atp, ap3a, ap4a and ap5a 1.24Å AUTH M.D.BAKER,D.E.HOLLOWAY,G.J.SWAMINATHAN,K.R.ACHARYATITL CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVEDTITL 2 NEUROTOXIN (EDN) IN COMPLEX WITH THE INHIBITORSTITL 3 5- ATP, AP(3)A, AP(4)A, AND AP(5)A.REF BIOCHEMISTRY V. 45 416 2006REFN ISSN 0006-2960PMID 16401072DOI 10.1021/BI0518592 Variant Set Distributions Mapped […]
General Structure Information 4i0p HLA-DOA hla-do in complex with hla-dm 3.2Å AUTH A.I.GUCE,S.E.MORTIMER,T.YOON,C.A.PAINTER,W.JIANG,AUTH 2 E.D.MELLINS,L.J.STERNTITL HLA-DO ACTS AS A SUBSTRATE MIMIC TO INHIBIT HLA-DM BY ATITL 2 COMPETITIVE MECHANISM.REF NAT.STRUCT.MOL.BIOL. V. 20 90 2013REFN ISSN 1545-9993PMID 23222639DOI 10.1038/NSMB.2460 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1jmo SERPIND1 crystal structure of the heparin cofactor ii-s195a thrombin complex 2.2Å AUTH T.P.BAGLIN,R.W.CARRELL,F.C.CHURCH,C.T.ESMON,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF NATIVE AND THROMBIN-COMPLEXED HEPARINTITL 2 COFACTOR II REVEAL A MULTISTEP ALLOSTERIC MECHANISM.REF PROC.NATL.ACAD.SCI.USA V. 99 11079 2002REFN ISSN 0027-8424PMID 12169660DOI 10.1073/PNAS.162232399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1lq8 SERPINA5 crystal structure of cleaved protein c inhibitor 2.4Å AUTH J.A.HUNTINGTON,M.KJELLBERG,J.STENFLOTITL CRYSTAL STRUCTURE OF PROTEIN C INHIBITOR PROVIDES INSIGHTSTITL 2 INTO HORMONE BINDING AND HEPARIN ACTIVATIONREF STRUCTURE V. 11 205 2003REFN ISSN 0969-2126PMID 12575940DOI 10.1016/S0969-2126(02)00944-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lq8 SERPINA5 crystal structure of cleaved protein c inhibitor 2.4Å AUTH J.A.HUNTINGTON,M.KJELLBERG,J.STENFLOTITL CRYSTAL STRUCTURE OF PROTEIN C INHIBITOR PROVIDES INSIGHTSTITL 2 INTO HORMONE BINDING AND HEPARIN ACTIVATIONREF STRUCTURE V. 11 205 2003REFN ISSN 0969-2126PMID 12575940DOI 10.1016/S0969-2126(02)00944-9 Variant Set Distributions Mapped Variants
General Structure Information 2arq SERPINB2 human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh 1.85Å AUTH D.A.DI GIUSTO,A.P.SUTHERLAND,L.JANKOVA,S.J.HARROP,P.M.CURMI,AUTH 2 G.C.KINGTITL PLASMINOGEN ACTIVATOR INHIBITOR-2 IS HIGHLY TOLERANT TO P8TITL 2 RESIDUE SUBSTITUTION–IMPLICATIONS FOR SERPIN MECHANISTICTITL 3 MODEL AND PREDICTION OF NSSNP ACTIVITIESREF J.MOL.BIOL. V. 353 1069 2005REFN ISSN 0022-2836PMID 16214170DOI 10.1016/J.JMB.2005.09.008 Variant Set Distributions […]
General Structure Information 2vwm F10 aminopyrrolidine factor xa inhibitor 1.96Å AUTH K.G.ZBINDEN,L.ANSELM,D.W.BANNER,J.M.BENZ,F.BLASCO,AUTH 2 G.DECORET,J.HIMBER,B.KUHN,N.PANDAY,F.RICKLIN,AUTH 3 P.RISCH,D.SCHLATTER,M.STAHL,S.THOMI,R.UNGER,W.HAAPTITL DESIGN OF NOVEL AMINOPYRROLIDINE FACTOR XATITL 2 INHIBITORS FROM A SCREENING HIT.REF EUR.J.MED.CHEM. V. 44 2787 2009REFN ISSN 0223-5234PMID 19200624DOI 10.1016/J.EJMECH.2008.12.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mfv AMY1B probing the role of a mobile loop in human slaivary amylase: structural studies on the loop-deleted enzyme 2.0Å AUTH N.RAMASUBBU,C.RAGUNATH,P.J.MISHRATITL PROBING THE ROLE OF A MOBILE LOOP IN SUBSTRATETITL 2 BINDING AND ENZYME ACTIVITY OF HUMAN SALIVARYTITL 3 AMYLASE.REF J.MOL.BIOL. V. 325 1061 2003REFN ISSN 0022-2836PMID 12527308DOI 10.1016/S0022-2836(02)01326-8 Variant Set […]
General Structure Information 1mfv AMY1C probing the role of a mobile loop in human slaivary amylase: structural studies on the loop-deleted enzyme 2.0Å AUTH N.RAMASUBBU,C.RAGUNATH,P.J.MISHRATITL PROBING THE ROLE OF A MOBILE LOOP IN SUBSTRATETITL 2 BINDING AND ENZYME ACTIVITY OF HUMAN SALIVARYTITL 3 AMYLASE.REF J.MOL.BIOL. V. 325 1061 2003REFN ISSN 0022-2836PMID 12527308DOI 10.1016/S0022-2836(02)01326-8 Variant Set […]
General Structure Information 1mfv AMY1A probing the role of a mobile loop in human slaivary amylase: structural studies on the loop-deleted enzyme 2.0Å AUTH N.RAMASUBBU,C.RAGUNATH,P.J.MISHRATITL PROBING THE ROLE OF A MOBILE LOOP IN SUBSTRATETITL 2 BINDING AND ENZYME ACTIVITY OF HUMAN SALIVARYTITL 3 AMYLASE.REF J.MOL.BIOL. V. 325 1061 2003REFN ISSN 0022-2836PMID 12527308DOI 10.1016/S0022-2836(02)01326-8 Variant Set […]