Assessment of Structural Intolerance and Durability
General Structure Information 1a3q NFKB2 human nf-kappa-b p52 bound to dna 2.1Å AUTH P.CRAMER,C.J.LARSON,G.L.VERDINE,C.W.MULLERTITL STRUCTURE OF THE HUMAN NF-KAPPAB P52 HOMODIMER-DNATITL 2 COMPLEX AT 2.1 A RESOLUTION.REF EMBO J. V. 16 7078 1997REFN ISSN 0261-4189PMID 9384586DOI 10.1093/EMBOJ/16.23.7078 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3zd2 CFHR1 the structure of the two n-terminal domains of complement factor h related protein 1 shows formation of a novel dimerisation interface 1.99Å AUTH E.GOICOECHEA DE JORGE,J.J.E.CAESAR,T.H.MALIK,M.PATEL,AUTH 2 M.COLLEDGE,S.JOHNSON,S.HAKOBYAN,B.P.MORGAN,C.L.HARRIS,AUTH 3 M.C.PICKERING,S.M.LEATITL DIMERIZATION OF COMPLEMENT FACTOR H-RELATED PROTEINSTITL 2 MODULATES COMPLEMENT ACTIVATION IN VIVO.REF PROC.NATL.ACAD.SCI.USA V. 110 4685 2013REFN ISSN 0027-8424PMID 23487775DOI […]
General Structure Information 4ag4 DDR1 crystal structure of a ddr1-fab complex 2.8Å AUTH F.CARAFOLI,M.C.MAYER,K.SHIRAISHI,M.A.PECHEVA,L.Y.CHAN,R.NAN,AUTH 2 B.LEITINGER,E.HOHENESTERTITL STRUCTURE OF THE DISCOIDIN DOMAIN RECEPTOR 1 EXTRACELLULARTITL 2 REGION BOUND TO AN INHIBITORY FAB FRAGMENT REVEALS FEATURESTITL 3 IMPORTANT FOR SIGNALING.REF STRUCTURE V. 20 688 2012REFN ISSN 0969-2126PMID 22483115DOI 10.1016/J.STR.2012.02.011 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4kc3 IL1RL1 cytokine/receptor binary complex 3.27Å AUTH X.LIU,M.HAMMEL,Y.HE,J.A.TAINER,U.S.JENG,L.ZHANG,S.WANG,AUTH 2 X.WANGTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF IL-33 WITH ITSTITL 2 RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 110 14918 2013REFN ISSN 0027-8424PMID 23980170DOI 10.1073/PNAS.1308651110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4n0f FCGRT human fcrn complexed with human serum albumin 3.02Å AUTH V.OGANESYAN,M.M.DAMSCHRODER,K.E.COOK,Q.LI,C.GAO,H.WU,AUTH 2 W.F.DALLACQUATITL STRUCTURAL INSIGHTS INTO NEONATAL FC RECEPTOR-BASEDTITL 2 RECYCLING MECHANISMS.REF J.BIOL.CHEM. V. 289 7812 2014REFN ISSN 0021-9258PMID 24469444DOI 10.1074/JBC.M113.537563 Variant Set Distributions Mapped Variants
General Structure Information 4f8q BTN3A2 crystal structure of the human btn3a2 ectodomain 2.38Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSES BY CD277/BUTYROPHILIN-3TITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2yuz MYBPC1 solution structure of 4th immunoglobulin domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF 4TH IMMUNOGLOBULIN DOMAIN OFTITL 2 SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ub2 TIRAP tir domain of mal/tirap 2.4Å AUTH Z.LIN,J.LU,W.ZHOU,Y.SHENTITL STRUCTURAL INSIGHTS INTO TIR DOMAIN SPECIFICITY OF THETITL 2 BRIDGING ADAPTOR MAL IN TLR4 SIGNALINGREF PLOS ONE V. 7 34202 2012REFN ESSN 1932-6203PMID 22485159DOI 10.1371/JOURNAL.PONE.0034202 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants